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Declaration of common standards for the preregistration of animal research—speeding up the scientific progress
ReferenceCéline Heinl , Anna M D Scholman-Végh , David Mellor , Gilbert Schönfelder , Daniel Strech , Steven Chamuleau , Bettina Bert PNAS Nexus. 2022;1(1):pgac016. doi: 10.1093/pnasnexus/pgac016 Preregistration of studies is a recognized tool in clinical research …
Cryopreserved human precision-cut lung slices provide an immune competent pulmonary test system for “on-demand” use and long-term cultures
ReferenceVivek S Patel , Khalid Amin , Adam Wahab , Méry Marimoutou , Lindsey Ukishima , Jose Alvarez , Kelley Battle , Andreas O Stucki , Amy J Clippinger , Holger P Behrsing Toxicological Sciences. 2023;191(2):253-265. doi: 10.1093/toxsci/kfac136 Human …
The fate of surplus laboratory animals: Minimizing the production of surplus animals has greatest potential to reduce the number of laboratory animals
ReferenceHartmut Wewetzer , Tobias Wagenknecht , Bettina Bert , Gilbert Schönfelder EMBO Reports. 2023;24(3):e56551. doi: 10.15252/embr.202256551 To meet regulatory requirements and the political pressure to minimize the number of animals used in research, it is …
Genetic engineering of animals: Ethical issues, including welfare concerns
ReferenceElisabeth H. Ormandy , Julie Dale , Gilly Griffin The Canadian Veterinary Journal. 2011;52(5):544-550. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078015/ Library Collection(s) Ethics, policy, and legislation Download Citation BibTeX EndNote X3 XML …
What Have Organoids and Assembloids Taught Us About the Pathophysiology of Neuropsychiatric Disorders?
ReferenceRebecca J. Levy , Sergiu P. Pașca Biological Psychiatry. 2023;93(7):632-641. doi: 10.1016/j.biopsych.2022.11.017 Neuropsychiatric research has been impeded by limited access to human brain tissue, especially from early stages of neurodevelopment when the …
Re-formation of synaptic connectivity in dissociated human stem cell-derived retinal organoid cultures
ReferenceAllison L. Ludwig , Steven J. Mayerl , Yu Gao , Mark Banghart , Cole Bacig , Maria A. Fernandez Zepeda , Xinyu Zhao , David M. Gamm Proceedings of the National Academy of Sciences. 2023;120(2):e2213418120. doi: 10.1073/pnas.2213418120 Human pluripotent …
Examining the effects of alcohol on GABAA receptor mRNA expression and function in neural cultures generated from control and alcohol dependent donor induced pluripotent stem cells
ReferenceRichard Lieberman , Henry R. Kranzler , Eric S. Levine , Jonathan Covault Alcohol. 2018;66:45-53. doi: 10.1016/j.alcohol.2017.08.005 Factors influencing the development of alcohol-use disorder (AUD) are complex and heterogeneous. While animal models have …
CYP3A5 Mediates Effects of Cocaine on Human Neocorticogenesis: Studies using an In Vitro 3D Self-Organized hPSC Model with a Single Cortex-Like Unit
ReferenceChun-Ting Lee , Jia Chen , Abigail A. Kindberg , Raphael M. Bendriem , Charles E. Spivak , Melanie P. Williams , Christopher T. Richie , Annelie Handreck , Barbara S. Mallon , Carl R. Lupica , Da-Ting Lin , Brandon K. Harvey , Deborah C. Mash , William J. …
In Silico Toxicology Data Resources to Support Read-Across and (Q)SAR
ReferenceGopal Pawar , Judith C. Madden , David Ebbrell , James W. Firman , Mark T. D. Cronin Frontiers in Pharmacology. 2019;10. A plethora of databases exist online that can assist in in silico chemical or drug safety assessment. However, a systematic review and …
Toward Parsimony in Bias Research: A Proposed Common Framework of Belief-Consistent Information Processing for a Set of Biases
ReferenceAileen Oeberst , Roland Imhoff Perspectives on Psychological Science. 2023;18(6):17456916221148147. doi: 10.1177/17456916221148147 One of the essential insights from psychological research is that people’s information processing is often biased. By now, a …