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Elucidation of the liver pathophysiology of COVID-19 patients using liver-on-a-chips
ReferenceSayaka Deguchi , Kaori Kosugi , Rina Hashimoto , Ayaka Sakamoto , Masaki Yamamoto , Rafal P Krol , Peter Gee , Ryosuke Negoro , Takeshi Noda , Takuya Yamamoto , Yu-suke Torisawa , Miki Nagao , Kazuo Takayama PNAS Nexus. 2023;2(3):pgad029. doi: …
How do scientists model humanness? A qualitative study of human organoids in biomedical research
ReferenceAmy Hinterberger , Sara Bea Social Science & Medicine. 2023;320:115676. doi: 10.1016/j.socscimed.2023.115676 We investigate how changes in biotechnology are transforming the pursuit of human-specific models of disease and development. Our case study …
(Bio)printing in Personalized Medicine—Opportunities and Potential Benefits
ReferenceDobromira Shopova , Antoniya Yaneva , Desislava Bakova , Anna Mihaylova , Petya Kasnakova , Maria Hristozova , Yordan Sbirkov , Victoria Sarafian , Mariya Semerdzhieva Bioengineering. 2023;10(3):287. doi: 10.3390/bioengineering10030287 The global …
Blood Vessel Organoids for Development and Disease
ReferenceKirill Salewskij , Josef M. Penninger Circulation Research. 2023;132(4):498-510. doi: 10.1161/CIRCRESAHA.122.321768 Despite enormous advances, cardiovascular disorders are still a major threat to global health and are responsible for one-third of deaths …
How Organ-on-a-Chip Technology Can Assist in Studying the Role of the Glymphatic System in Neurodegenerative Diseases
ReferenceSarah Spitz , Eunkyung Ko , Peter Ertl , Roger D. Kamm International Journal of Molecular Sciences. 2023;24(3):2171. doi: 10.3390/ijms24032171 The lack of a conventional lymphatic system that permeates throughout the entire human brain has encouraged the …
3D in vitro modelling of human patient microglia: A focus on clinical translation and drug development in neurodegenerative diseases
ReferenceCarla CunÃ-López , Romal Stewart , Anthony R. White , Hazel Quek Journal of Neuroimmunology. 2023;375:578017. doi: 10.1016/j.jneuroim.2023.578017 Microglia have an increasingly well-recognised role in the pathogenesis of neurodegenerative diseases, …
Predicting human cardiac QT alterations and pro-arrhythmic effects of compounds with a 3D beating heart-on-chip platform
ReferenceRoberta Visone , Ferran Lozano-Juan , Simona Marzorati , Massimo Walter Rivolta , Enrico Pesenti , Alberto Redaelli , Roberto Sassi , Marco Rasponi , Paola Occhetta Toxicological Sciences. 2023;191(1):47-60. doi: 10.1093/toxsci/kfac108 Determining the …
In vitro functional models for human liver diseases and drug screening: beyond animal testing
ReferenceAlessia Paradiso , Marina Volpi , Chiara Rinoldi , Nehar Celikkin , Nicola Contessi Negrini , Muge Bilgen , Giorgio Dallera , Filippo Pierini , Marco Costantini , Wojciech Święszkowski , Silvia Farè Biomaterials Science. 2023;11(9):2988-3015. doi: …
Transition from Animal-Based to Human Induced Pluripotent Stem Cells (iPSCs)-Based Models of Neurodevelopmental Disorders: Opportunities and Challenges
ReferenceSara Guerreiro , PatrÃcia Maciel Cells. 2023;12(4):538. doi: 10.3390/cells12040538 Neurodevelopmental disorders (NDDs) arise from the disruption of highly coordinated mechanisms underlying brain development, which results in impaired sensory, motor and/or …
Microfluidic study of retention and elimination of abnormal red blood cells by human spleen with implications for sickle cell disease
ReferenceYuhao Qiang , Abdoulaye Sissoko , Zixiang L. Liu , Ting Dong , Fuyin Zheng , Fang Kong , John M. Higgins , George E. Karniadakis , Pierre A. Buffet , Subra Suresh , Ming Dao Proceedings of the National Academy of Sciences. 2023;120(6):e2217607120. doi: …