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Compassion Fatigue in Laboratory Animal Personnel during the COVID-19 Pandemic
ReferenceSarah E Thurston , Goldia Chan , Lisa A Burlingame , Jennifer A Jones , Patrick A Lester , Tara L Martin Journal of the American Association for Laboratory Animal Science. 2021;60(6):646-654. doi: 10.30802/AALAS-JAALAS-21-000030 Compassion Fatigue (CF) is …
iPSC-derived liver organoids and inherited bleeding disorders: Potential and future perspectives
ReferenceGiacomo Roman , Benedicte Stavik , Knut H. Lauritzen , Per Morten Sandset , Sean P. Harrison , Gareth J. Sullivan , Maria Eugenia Chollet Frontiers in Physiology. 2023;14. The bleeding phenotype of hereditary coagulation disorders is caused by the low or …
Hemostasis-on-a-chip / incorporating the endothelium in microfluidic models of bleeding
ReferenceYumiko Sakurai , Elaissa T. Hardy , Wilbur A. Lam Platelets. 2023;34(1):2185453. doi: 10.1080/09537104.2023.2185453 Currently, point-of-care assays for human platelet function and coagulation are used to assess bleeding risks and drug testing, but they …
Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity
ReferenceElisa Passini , Oliver J. Britton , Hua Rong Lu , Jutta Rohrbacher , An N. Hermans , David J. Gallacher , Robert J. H. Greig , Alfonso Bueno-Orovio , Blanca Rodriguez Frontiers in Physiology. 2017;8. Early prediction of cardiotoxicity is critical for drug …
Modeling of three-dimensional innervated epidermal like-layer in a microfluidic chip-based coculture system
ReferenceJinchul Ahn , Kyungeun Ohk , Jihee Won , Dong-Hee Choi , Yong Hun Jung , Ji Hun Yang , Yesl Jun , Jin-A. Kim , Seok Chung , Sang-Hoon Lee Nature Communications. 2023;14(1):1488. doi: 10.1038/s41467-023-37187-4 Reconstruction of skin equivalents with …
How stable is your vivarium's temperature? Fluctuations in vivarium temperature significantly impact metabolism and behavior impeding scientific reproducibility
ReferenceChristian A. Unger , Marion C Hope , Ahmed K. Aladhami , Kandy T. Velázquez , Reilly T. Enos Physiology & Behavior. 2023;258:114029. doi: 10.1016/j.physbeh.2022.114029 Objectives The purpose of this investigation was to examine the variability in vivarium …
How STRANGE are your study animals?
ReferenceMichael M. Webster , Christian Rutz Nature. 2020;582:337-340. doi: 10.1038/d41586-020-01751-5 A new framework for animal-behaviour research will help to avoid sampling bias — ten years on from the call to widen the pool of human participants in psychology …
A Human Ovarian Tumor & Liver Organ-on-Chip for Simultaneous and More Predictive Toxo-Efficacy Assays
ReferenceArianna Fedi , Chiara Vitale , Marco Fato , Silvia Scaglione Bioengineering. 2023;10(2):270. doi: 10.3390/bioengineering10020270 In oncology, the poor success rate of clinical trials is becoming increasingly evident due to the weak predictability of …
Network and Microcircuitry Development in Human Brain Organoids
ReferenceFrancesca Puppo , Alysson Renato Muotri Biological Psychiatry. 2023;93(7):590-593. doi: 10.1016/j.biopsych.2022.07.006 https://www.biologicalpsychiatryjournal.com/article/S0006-3223(22)01437-8/fulltext Library Collection(s) Nervous system Download …
Blood brain barrier-on-a-chip to model neurological diseases
ReferenceS. Reshma , K. B. Megha , S. Amir , S. Rukhiya , P. V. Mohanan Journal of Drug Delivery Science and Technology. 2023;80:104174. doi: 10.1016/j.jddst.2023.104174 The blood-brain barrier (BBB) is a vital and unique multi-dimensional selective barrier that …