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Open questions in human lung organoid research
ReferenceTessa Hughes , Krijn K. Dijkstra , Emma L. Rawlins , Robert E. Hynds Frontiers in Pharmacology. 2023;13. Organoids have become a prominent model system in pulmonary research. The ability to establish organoid cultures directly from patient tissue has …
Human brain microphysiological systems in the study of neuroinfectious disorders
ReferencePaula Barreras , David Pamies , Thomas Hartung , Carlos A. Pardo Experimental Neurology. 2023;365:114409. doi: 10.1016/j.expneurol.2023.114409 Microphysiological systems (MPS) are 2D or 3D multicellular constructs able to mimic tissue microenvironments. …
Cerebral organoids in primary progressive multiple sclerosis reveal stem cell and oligodendrocyte differentiation defect
ReferenceNicolas Daviaud , Eric Chen , Tara Edwards , Saud A. Sadiq Biology Open. 2023;12(3):bio059845. doi: 10.1242/bio.059845 Multiple sclerosis (MS) is an auto-immune inflammatory disorder affecting the central nervous system. The cause of the disease is …
Heart-on-a-Chip: Leveraging Technology for Sickle Cell Disease
ReferenceJordyn Folh , Renita E. Horton , Ralf Martz Sulague , Jacques Kpodonu JACC: Advances. 2023;2(4):100355. doi: 10.1016/j.jacadv.2023.100355 https://www.jacc.org/doi/full/10.1016/j.jacadv.2023.100355 Keywords in vitro modeling sickle cell disease technology …
Stem Cell–Based Organoid Models of Neurodevelopmental Disorders
ReferenceLu Wang , Charlotte Owusu-Hammond , David Sievert , Joseph G. Gleeson Biological Psychiatry. 2023;93(7):622-631. doi: 10.1016/j.biopsych.2023.01.012 The past decade has seen an explosion in the identification of genetic causes of neurodevelopmental …
3D engineered tissue models for studying human-specific infectious viral diseases
ReferenceKyeong Seob Hwang , Eun U Seo , Nakwon Choi , Jongbaeg Kim , Hong Nam Kim Bioactive Materials. 2023;21:576-594. doi: 10.1016/j.bioactmat.2022.09.010 Viral infections cause damage to various organ systems by inducing organ-specific symptoms or systemic …
A Short History of the Consideration of Sex Differences in Biomedical Research — Lessons for the In Vitro Community from Animal Models and Human Clinical Trials
ReferenceHelena Niobe Renate Gutleb , Arno Christian Gutleb Alternatives to Laboratory Animals. 2023;51(2):144-150. doi: 10.1177/02611929231156720 In recent decades, it has become clear that in many fields — such as drug development, particularly with regard to …
Unravelling Pathophysiology of Neurological and Psychiatric Complications of COVID-19 Using Brain Organoids
ReferenceJing-Han Ng , Alfred Sun , Hyunsoo Shawn Je , Eng-King Tan The Neuroscientist. 2023;29(1):30-40. doi: 10.1177/10738584211015136 Neuropsychiatric manifestations of coronavirus disease 2019 (COVID-19) have been increasingly recognized. However, the …
Gene expression in organoids: an expanding horizon
ReferenceArtem Smirnov , Gerry Melino , Eleonora Candi Biology Direct. 2023;18(1):11. doi: 10.1186/s13062-023-00360-2 Recent development of human three-dimensional organoid cultures has opened new doors and opportunities ranging from modelling human development in …
Statistical analysis of preclinical inter-species concordance of histopathological findings in the eTOX database
ReferencePeter S. R. Wright , Katharine A. Briggs , Robert Thomas , Graham F. Smith , Gareth Maglennon , Paulius Mikulskis , Melissa Chapman , Nigel Greene , Benjamin U. Phillips , Andreas Bender Regulatory Toxicology and Pharmacology. 2023;138:105308. doi: …