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In silico clinical trial evaluating lisdexamfetamine’s and methylphenidate’s mechanism of action computational models in an attention-deficit/hyperactivity disorder virtual patients’ population
ReferenceJosé Ramón Gutiérrez-Casares , Javier Quintero , Cristina Segú-Vergés , Pilar RodrÃguez Monterde , Tamara Pozo-Rubio , Mireia Coma , Carmen Montoto Frontiers in Psychiatry. 2023;14:939650. doi: 10.3389/fpsyt.2023.939650 Introduction …
Spontaneous Epileptic Recordings from hiPSC-Derived Cortical Neurons Cultured with a Human Epileptic Brain Biopsy on a Multi Electrode Array
ReferenceMichel H. Y. Hu , Jean-Philippe Frimat , Kim Rijkers , Olaf E. M. G. Schijns , Arn M. J. M. van den Maagdenberg , Jim T. A. Dings , Regina Luttge , Govert Hoogland Applied Sciences. 2023;13(3):1432. doi: 10.3390/app13031432 A growing societal awareness is …
Alzheimer’s disease: experimental models and reality
ReferenceEleanor Drummond , Thomas Wisniewski Acta Neuropathologica. 2016;133(2):155-175. doi: 10.1007/s00401-016-1662-x Experimental models of Alzheimer’s disease (AD) are critical to gaining a better understanding of pathogenesis and to assess the potential of …
Mouse models rarely mimic the transcriptome of human neurodegenerative diseases: A systematic bioinformatics-based critique of preclinical models
ReferenceTerry C. Burns , Matthew D. Li , Swapnil Mehta , Ahmed J. Awad , Alexander A. Morgan European Journal of Pharmacology. 2015;759:101-117. doi: 10.1016/j.ejphar.2015.03.021 Translational research for neurodegenerative disease depends intimately upon animal …
From a mouse: systematic analysis reveals limitations of experiments testing interventions in Alzheimer's disease mouse models
ReferenceK. J. Egan , H. M. Vesterinen , V. Beglopoulos , Emily S. Sena , Malcolm R. Macleod Evidence-based Preclinical Medicine. 2016;3(1):e00015. doi: 10.1002/ebm2.15 The increasing prevalence of Alzheimer's disease (AD) poses a considerable socio-economic …
Are some animal models more equal than others? A case study on the translational value of animal models of efficacy for Alzheimer's disease
ReferenceDésirée H. Veening-Griffioen , Guilherme S. Ferreira , Peter J. K. Van Meer , Wouter P. C. Boon , Christine C. Gispen-de Wied , Ellen H. M. Moors , Huub Schellekens European Journal of Pharmacology. 2019;859:172524. doi: 10.1016/j.ejphar.2019.172524 …
Microfluidic device facilitates in vitro modeling of human neonatal necrotizing enterocolitis–on-a-chip
ReferenceWyatt E. Lanik , Cliff J. Luke , Lila S. Nolan , Qingqing Gong , Lauren C. Frazer , Jamie M. Rimer , Sarah E. Gale , Raymond Luc , Shay S. Bidani , Carrie A. Sibbald , Angela N. Lewis , Belgacem Mihi , Pranjal Agrawal , Martin Goree , Marlie Maestas , …
A benchtop brain injury model using resected donor tissue from patients with Chiari malformation
ReferenceJacqueline A. Tickle , Jon Sen , Christopher Adams , David N. Furness , Rupert Price , Viswapathi Kandula , Nikolaos Tzerakis , Divya M. Chari Neural Regeneration Research. 2023;18(5):1057. doi: 10.4103/1673-5374.355761 The use of live animal models for …
The Application of New Approach Methodologies in Respiratory Disease Research: Their Role in Improving Translational Medicine from Bench to Bedside
ReferenceArtur C.G. da Silva , Marize C. Valadares Alternatives to Laboratory Animals. 2023;51(3):161-174. doi: 10.1177/02611929231170392 The SARS-CoV-2 outbreak focused global attention on the shortcomings of the drug discovery process. It led to its acceleration …
Next generation organoid engineering to replace animals in cancer drug testing
ReferenceSean Hockney , Jessica Parker , Jasmin E. Turner , Xanthea Todd , Stephen Todryk , Roben Ger Gieling , Gerrit Hilgen , Davina Camargo Madeira Simoes , Deepali Pal Biochemical Pharmacology. 2023;213:115586. doi: 10.1016/j.bcp.2023.115586 Cancer therapies …