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Engineered extracellular matrices facilitate brain organoids from human pluripotent stem cells
ReferenceAyşe J. Muñiz , Tuğba Topal , Michael D. Brooks , Angela Sze , Do Hoon Kim , Jacob Jordahl , Joe Nguyen , Paul H. Krebsbach , Masha G. Savelieff , Eva L. Feldman , Joerg Lahann Annals of Clinical and Translational Neurology. 2023;10(7):1239-1253. doi: …
The role of extracellular vesicles in non-small-cell lung cancer, the unknowns, and how new approach methodologies can support new knowledge generation in the field
ReferenceSive Mullen , Dania Movia European Journal of Pharmaceutical Sciences. 2023;188:106516. doi: 10.1016/j.ejps.2023.106516 Extracellular vesicles (EVs) are nanosized particles released from most human cell types that contain a variety of cargos responsible …
Human 3D brain organoids: steering the demolecularization of brain and neurological diseases
ReferenceYogita K. Adlakha Cell Death Discovery. 2023;9(1):1-17. doi: 10.1038/s41420-023-01523-w Understanding of human brain development, dysfunction and neurological diseases has remained limited and challenging due to inability to recapitulate human …
A multi-organoid platform identifies CIART as a key factor for SARS-CoV-2 infection
ReferenceXuming Tang , Dongxiang Xue , Tuo Zhang , Benjamin E. Nilsson-Payant , Lucia Carrau , Xiaohua Duan , Miriam Gordillo , Adrian Y. Tan , Yunping Qiu , Jenny Xiang , Robert E. Schwartz , Benjamin R. tenOever , Todd Evans , Shuibing Chen Nature Cell Biology. …
A systematic review of kidney-on-a-chip-based models to study human renal (patho-)physiology
ReferenceVivian V. T. Nguyen , Vasiliki Gkouzioti , Christian Maass , Marianne C. Verhaar , Robin W. M. Vernooij , Bas W. M. van Balkom Disease Models & Mechanisms. 2023;16(6):dmm050113. doi: 10.1242/dmm.050113 As kidney diseases affect ∼10% of the world …
Epicardioid single-cell genomics uncovers principles of human epicardium biology in heart development and disease
ReferenceAnna B. Meier , Dorota Zawada , Maria Teresa De Angelis , Laura D. Martens , Gianluca Santamaria , Sophie Zengerle , Monika Nowak-Imialek , Jessica Kornherr , Fangfang Zhang , Qinghai Tian , Cordula M. Wolf , Christian Kupatt , Makoto Sahara , Peter Lipp …
Muscle-on-a-chip devices: a new era for in vitro modelling of muscular dystrophies
ReferenceJuan M. Fernández-Costa , Ainoa Tejedera-Vilafranca , Xiomara Fernández-Garibay , Javier Ramón-Azcón Disease Models & Mechanisms. 2023;16(6):dmm050107. doi: 10.1242/dmm.050107 Muscular dystrophies are a heterogeneous group of highly debilitating diseases …
Organotypic human lung bud microarrays identify BMP-dependent SARS-CoV-2 infection in lung cells
ReferenceE. A. Rosado-Olivieri , B. Razooky , J. Le Pen , R. De Santis , D. Barrows , Z. Sabry , H. -H. Hoffmann , J. Park , T. S. Carroll , J. T. Poirier , C. M. Rice , A. H. Brivanlou Stem Cell Reports. 2023;18(5):1107-1122. doi: 10.1016/j.stemcr.2023.03.015 …
Schizophrenia-associated NRXN1 deletions induce developmental-timing- and cell-type-specific vulnerabilities in human brain organoids
ReferenceRebecca Sebastian , Kang Jin , Narciso Pavon , Ruby Bansal , Andrew Potter , Yoonjae Song , Juliana Babu , Rafael Gabriel , Yubing Sun , Bruce Aronow , ChangHui Pak Nature Communications. 2023;14(1):3770. doi: 10.1038/s41467-023-39420-6 De novo mutations …
Pushing the boundaries of brain organoids to study Alzheimer’s disease
ReferenceJonas Cerneckis , Guojun Bu , Yanhong Shi Trends in Molecular Medicine. 2023;29(8):659-672. doi: 10.1016/j.molmed.2023.05.007 https://www.cell.com/trends/molecular-medicine/abstract/S1471-4914(23)00098-9 Keywords Alzheimer’s disease Apolipoprotein E4 …