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Genetics of human brain development
ReferenceYi Zhou , Hongjun Song , Guo-li Ming Nature Reviews Genetics. 2023:1-20. doi: 10.1038/s41576-023-00626-5 Brain development in humans is achieved through precise spatiotemporal genetic control, the mechanisms of which remain largely elusive. Recently, …
Micro-Engineered Organoid-on-a-Chip Based on Mesenchymal Stromal Cells to Predict Immunotherapy Responses of HCC Patients
ReferenceZhengyu Zou , Zhun Lin , Chenglin Wu , Jizhou Tan , Jie Zhang , Yanwen Peng , Kunsong Zhang , Jiaping Li , Minhao Wu , Yuanqing Zhang Advanced Science. ;n/a(n/a):2302640. doi: 10.1002/advs.202302640 Hepatocellular carcinoma (HCC) is one of the most lethal …
A Platform for Assessing Cellular Contractile Function Based on Magnetic Manipulation of Magnetoresponsive Hydrogel Films
ReferenceMoran Yadid , Mario Hagel , Megan Beldjilali Labro , Baptiste Le Roi , Carina Flaxer , Eli Flaxer , A. Ronny Barnea , Shai Tejman-Yarden , Eric Silberman , Xin Li , Rossana Rauti , Yael Leichtmann-Bardoogo , Hongyan Yuan , Ben M. Maoz Advanced Science. …
Symmetry Breaking of Human Pluripotent Stem Cells (hPSCs) in Micropattern Generates a Polarized Spinal Cord-Like Organoid (pSCO) with Dorsoventral Organization
ReferenceKyubin Seo , Subin Cho , Hyogeun Shin , Aeri Shin , Ju-Hyun Lee , June Hoan Kim , Boram Lee , Hwanseok Jang , Youngju Kim , Hyo Min Cho , Yongdoo Park , Hee Youn Kim , Taeseob Lee , Woong-Yang Park , Yong Jun Kim , Esther Yang , Dongho Geum , Hyun Kim , …
Building blocks of microphysiological system to model physiology and pathophysiology of human heart
ReferenceHanna Vuorenpää , Miina Björninen , Hannu Välimäki , Antti Ahola , Mart Kroon , Laura Honkamäki , Jussi T. Koivumäki , Mari Pekkanen-Mattila Frontiers in Physiology. 2023;14:1213959. doi: 10.3389/fphys.2023.1213959 Microphysiological systems (MPS) are …
The role of insulin/IGF1 signalling in neurodevelopmental and neuropsychiatric disorders – Evidence from human neuronal cell models
ReferenceJános M. Réthelyi , Katalin Vincze , Dorothea Schall , Jeffrey Glennon , Simone Berkel Neuroscience & Biobehavioral Reviews. 2023;153:105330. doi: 10.1016/j.neubiorev.2023.105330 Insulin and insulin-like growth factor 1 (IGF1) signalling play a central …
The Growing Importance of Three-Dimensional Models and Microphysiological Systems in the Assessment of Mycotoxin Toxicity
ReferenceVeronica Zingales , Maria Rosaria Esposito , Noemi Torriero , Mercedes Taroncher , Elisa Cimetta , MarÃa-José Ruiz Toxins. 2023;15(7):422. doi: 10.3390/toxins15070422 Current investigations in the field of toxicology mostly rely on 2D cell cultures and …
Fibre-infused gel scaffolds guide cardiomyocyte alignment in 3D-printed ventricles
ReferenceSuji Choi , Keel Yong Lee , Sean L. Kim , Luke A. MacQueen , Huibin Chang , John F. Zimmerman , Qianru Jin , Michael M. Peters , Herdeline Ann M. Ardoña , Xujie Liu , Ann-Caroline Heiler , Rudy Gabardi , Collin Richardson , William T. Pu , Andreas R. …
Human induced pluripotent stem cell–derived liver-on-a-chip for studying drug metabolism: the challenge of the cytochrome P450 family
ReferenceIsabel Tamargo-Rubio , Anna Bella Simpson , Joanne A. Hoogerland , Jingyuan Fu Frontiers in Pharmacology. 2023;14. The liver is the primary organ responsible for the detoxification and metabolism of drugs. To date, a lack of preclinical models that …
An atlas of healthy and injured cell states and niches in the human kidney
ReferenceBlue B. Lake , Rajasree Menon , Seth Winfree , Qiwen Hu , Ricardo Melo Ferreira , Kian Kalhor , Daria Barwinska , Edgar A. Otto , Michael Ferkowicz , Dinh Diep , Nongluk Plongthongkum , Amanda Knoten , Sarah Urata , Laura H. Mariani , Abhijit S. Naik , …