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Protocol for designing INVITES-IN, a tool for assessing the internal validity of in vitro studies
ReferenceCamilla Svendsen , Paul Whaley , Gunn E. Vist , Trine Husøy , Anna Beronius , Emma Di Consiglio , Ingrid Druwe , Thomas Hartung , Vasiliki I. Hatzi , Sebastian Hoffmann , Carlijn R. Hooijmans , Kyriaki Machera , Joshua F. Robinson , Erwin Roggen , Andrew …
Engaging Ethicists in Animal Research Policymaking
ReferenceAngela N Hvitved ILAR Journal. 2019;60(3):318-323. doi: 10.1093/ilar/ilz023 The significance of ethical considerations for animal research policy has long been acknowledged, but the role of philosophical ethics in the policymaking process has been less …
International regulatory uses of acute systemic toxicity data and integration of new approach methodologies
ReferenceJudy Strickland , Esther Haugabrooks , David G. Allen , Luciene B. Balottin , Yoko Hirabayashi , Nicole C. Kleinstreuer , Hajime Kojima , Claudio Nishizawa , Pilar Prieto , Deborah E. Ratzlaff , Jayoung Jeong , JinHee Lee , Ying Yang , Pinpin Lin , …
Placenta-on-a-chip: Response of neural cells to pharmaceutical agents transported across the placental barrier
ReferenceRajeendra L. Pemathilaka , Nicole N. Hashemi Innovation and Emerging Technologies. 2023;10:2340004. doi: 10.1142/S2737599423400042 Striving for sustainable drug discovery, we have presented a proof-of-concept for studying the effects of pharmaceutical …
Sex differences in brain protein expression and disease
ReferenceAliza P. Wingo , Yue Liu , Ekaterina S. Gerasimov , Selina M. Vattathil , Jiaqi Liu , David J. Cutler , Michael P. Epstein , Gabriëlla A. M. Blokland , Madhav Thambisetty , Juan C. Troncoso , Duc M. Duong , David A. Bennett , Allan I. Levey , Nicholas T. …
Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer’s disease risk gene SORL1
ReferenceHyo Lee , Aimee J. Aylward , Richard V. Pearse , Alexandra M. Lish , Yi-Chen Hsieh , Zachary M. Augur , Courtney R. Benoit , Vicky Chou , Allison Knupp , Cheryl Pan , Srilakshmi Goberdhan , Duc M. Duong , Nicholas T. Seyfried , David A. Bennett , Mariko …
Advancing preclinical models of psychiatric disorders with human brain organoid cultures
ReferenceThomas Anthony Dixon , Alysson R. Muotri Molecular Psychiatry. 2023;28(1):83-95. doi: 10.1038/s41380-022-01708-2 Psychiatric disorders are often distinguished from neurological disorders in that the former do not have characteristic lesions or findings …
Development of brain organoid technology derived from iPSC for the neurodegenerative disease modelling: a glance through
ReferenceAmirah Syamimi Jusop , Kalaiselvaan Thanaskody , Gee Jun Tye , Sylvia Annabel Dass , Wan Safwani Wan Kamarul Zaman , Fazlina Nordin Frontiers in Molecular Neuroscience. 2023;16. Neurodegenerative diseases are adult-onset neurological conditions that are …
An integrated organoid omics map extends modeling potential of kidney disease
ReferenceMoritz Lassé , Jamal El Saghir , Celine C. Berthier , Sean Eddy , Matthew Fischer , Sandra D. Laufer , Dominik Kylies , Arvid Hutzfeldt , Léna Lydie Bonin , Bernhard Dumoulin , Rajasree Menon , Virginia Vega-Warner , Felix Eichinger , Fadhl Alakwaa , …
Investigating multi-material hydrogel three-dimensional printing for in vitro representation of the neo-vasculature of solid tumours: a comprehensive mechanical analysis and assessment of nitric oxide release from human umbilical vein endothelial cells
ReferenceLisa Asciak , Lauren Gilmour , Jonathan A. Williams , Euan Foster , Lara DÃaz-GarcÃa , Christopher McCormick , James F. C. Windmill , Helen E. Mulvana , Joseph C. Jackson-Camargo , Roger Domingo-Roca Royal Society Open Science. 2023;10(8):230929. doi: …