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Tackling rare diseases: Clinical trials on chips
ReferenceSandra H Blumenrath , Bo Y Lee , Lucie Low , Ranjini Prithviraj , Danilo Tagle Experimental Biology and Medicine. 2020;245(13):1155-1162. doi: 10.1177/1535370220924743 Technological advances with organs-on-chips and induced pluripotent stem cells promise …
How citation distortions create unfounded authority: analysis of a citation network
ReferenceSteven A. Greenberg BMJ. 2009;339:b2680. doi: 10.1136/bmj.b2680 Objective To understand belief in a specific scientific claim by studying the pattern of citations among papers stating it. Design A complete citation network was constructed from all PubMed …
Negative psychological aspects of working with experimental animals in scientific research
ReferenceHanna Mamzer , Agnieszka Zok , Piotr Białas , Mirosław Andrusiewicz PeerJ. 2021;9:e11035. doi: 10.7717/peerj.11035 The aim of the study was to reveal the negative psychological aspects of using animals by scientists and to determine whether the emotional …
Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes
ReferenceZachary S. Nevin , Daniel C. Factor , Robert T. Karl , Panagiotis Douvaras , Jeremy Laukka , Martha S. Windrem , Steven A. Goldman , Valentina Fossati , Grace M. Hobson , Paul J. Tesar American Journal of Human Genetics. 2017;100(4):617-634. doi: …
Human-specific NOTCH2NL genes affect Notch signaling and cortical neurogenesis
ReferenceIan T. Fiddes , Gerrald A. Lodewijk , Meghan Mooring , Colleen M. Bosworth , Adam D. Ewing , Gary L. Mantalas , Adam M. Novak , Anouk van den Bout , Alex Bishara , Jimi L. Rosenkrantz , Ryan Lorig-Roach , Andrew R. Field , Maximilian Haeussler , Lotte …
Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution
ReferenceCameron S. Cowan , Magdalena Renner , Martina De Gennaro , Brigitte Gross-Scherf , David Goldblum , Yanyan Hou , Martin Munz , Tiago M. Rodrigues , Jacek Krol , Tamas Szikra , Rachel Cuttat , Annick Waldt , Panagiotis Papasaikas , Roland Diggelmann , …
Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung
ReferenceJonas C. Schupp , Taylor S. Adams , Carlos Cosme , Micha Sam Brickman Raredon , Yifan Yuan , Norihito Omote , Sergio Poli , Maurizio Chioccioli , Kadi-Ann Rose , Edward P. Manning , Maor Sauler , Giuseppe DeIuliis , Farida Ahangari , Nir Neumark , Arun C. …
Biomimetic Approaches in Cardiac Tissue Engineering: Replicating the Native Heart Microenvironment
ReferenceAnoosha Khan , Priya Kumari , Naina Kumari , Usman Shaikh , Chukwuyem Ekhator , Raghu Halappa Nagaraj , Vikas Yadav , Aimen Waqar Khan , Slobodan Lazarevic , Bishal Bharati , Gautham Lakshmipriya Vetrivendan , Asmita Mulmi , Hana Mohamed , Ashraf Ullah , …
The role of organoids in cancer research
ReferenceZhen Fang , Peijuan Li , Fengying Du , Liang Shang , Leping Li Experimental Hematology & Oncology. 2023;12(1):69. doi: 10.1186/s40164-023-00433-y Organoids are established through in vitro 3D culture, and they can mimic the structure and physiological …
Patients’ attitudes towards animal testing: “To conduct research on animals is, I suppose, a necessary evil”
ReferenceMalin Masterton , Tobias Renberg , Sofia Kälvemark Sporrong BioSocieties. 2014;9(1):24-41. doi: 10.1057/biosoc.2013.39 A strong argument for the practice of animal testing in medical research is the potential benefit to patients in getting improved pain …