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Organs-on-chips: Progress, challenges, and future directions
ReferenceLucie A Low , Danilo A Tagle Experimental Biology and Medicine. 2017;242(16):1573-1578. doi: 10.1177/1535370217700523 The National Institutes of Health Microphysiological Systems (MPS) program, led by the National Center for Advancing Translational …
Microphysiological Systems: Stakeholder Challenges to Adoption in Drug Development
ReferencePassley Hargrove-Grimes , Lucie A. Low , Danilo A. Tagle Cells Tissues Organs. 2022;211(3):269-281. doi: 10.1159/000517422 Microphysiological systems (MPS) or tissue chips/organs-on-chips are novel in vitro models that emulate human physiology at …
Organs-on-chips: into the next decade
ReferenceLucie A. Low , Christine Mummery , Brian R. Berridge , Christopher P. Austin , Danilo A. Tagle Nature Reviews. Drug Discovery. 2021;20(5):345-361. doi: 10.1038/s41573-020-0079-3 Organs-on-chips (OoCs), also known as microphysiological systems or 'tissue …
Advanced Good Cell Culture Practice for human primary, stem cell-derived and organoid models as well as microphysiological systems
ReferenceDavid Pamies , Anna Bal-Price , Christophe Chesné , Sandra Coecke , Andras Dinnyes , Chantra Eskes , Regina Grillari , Gerhard Gstraunthaler , Thomas Hartung , Paul Jennings , Marcel Leist , Ulrich Martin , Robert Passier , Jens C. Schwamborn , Glyn N. …
Personalised organs-on-chips: functional testing for precision medicine
ReferenceAlbert van den Berg , Christine L. Mummery , Robert Passier , Andries D. van der Meer Lab on a Chip. 2019;19(2):198-205. doi: 10.1039/C8LC00827B https://pubs.rsc.org/en/content/articlelanding/2019/lc/c8lc00827b Library Collection(s) Precision medicine …
Publication rate in preclinical research: a plea for preregistration
ReferenceMira van der Naald , Steven Wenker , Pieter A. Doevendans , Kimberley E. Wever , Steven A. J. Chamuleau BMJ Open Science. 2020;4(1):e100051. doi: 10.1136/bmjos-2019-100051 Objectives The ultimate goal of biomedical research is the development of new …
Tradition, not science, is the basis of animal model selection in translational and applied research
ReferenceDésirée H. Veening-Griffioen , Guilherme S. Ferreira , Wouter P. C. Boon , Christine C. Gispen-de Wied , Huub Schellekens , Ellen H. M. Moors , Peter J. K. Van Meer ALTEX. 2021;38(1):49-62. doi: 10.14573/altex.2003301 National and international laws and …
Estimating mouse and rat use in American laboratories by extrapolation from Animal Welfare Act-regulated species
ReferenceLarry Carbone Scientific Reports. 2021;11(1):493. doi: 10.1038/s41598-020-79961-0 Alone among Western nations, the United States has a two-tier system for welfare protections for vertebrate animals in research. Because its Animal Welfare Act (AWA) …
Lost in translation: animal models and clinical trials in cancer treatment
ReferenceIsabella WY Mak , Nathan Evaniew , Michelle Ghert American Journal of Translational Research. 2014;6(2):114-118. Due to practical and ethical concerns associated with human experimentation, animal models have been essential in cancer research. However, …
Genomic responses in mouse models poorly mimic human inflammatory diseases
ReferenceJunhee Seok , H. Shaw Warren , Alex G. Cuenca , Michael N. Mindrinos , Henry V. Baker , Weihong Xu , Daniel R. Richards , Grace P. McDonald-Smith , Hong Gao , Laura Hennessy , Celeste C. Finnerty , Cecilia M. López , Shari Honari , Ernest E. Moore , …