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Pre-clinical Investigation of Rett Syndrome Using Human Stem Cell-Based Disease Models
ReferenceFlorencia D. Haase , Bronte Coorey , Lisa Riley , Laurence C. Cantrill , Patrick P. L. Tam , Wendy A. Gold Frontiers in Neuroscience. 2021;15. Rett syndrome (RTT) is an X-linked neurodevelopmental disorder, mostly caused by mutations in MECP2. The …
Editorial: In silico Methods for Drug Design and Discovery
ReferenceSimone Brogi , Teodorico Castro Ramalho , Kamil Kuca , José L. Medina-Franco , Marian Valko Frontiers in Chemistry. 2020;8. https://www.frontiersin.org/articles/10.3389/fchem.2020.00612 Library Collection(s) In Silico Download Citation BibTeX EndNote X3 …
Physiologically relevant human tissue models for infectious diseases
ReferenceMelody Mills , Mary K. Estes Drug Discovery Today. 2016;21(9):1540-1552. doi: 10.1016/j.drudis.2016.06.020 Limitations of animal infection models have engendered longstanding obstacles in basic science and translational research. Lack of suitable animal …
Alzheimer's disease drug-development pipeline: few candidates, frequent failures
ReferenceJeffrey L. Cummings , Travis Morstorf , Kate Zhong Alzheimer's Research & Therapy. 2014;6:37. doi: 10.1186/alzrt269 INTRODUCTION: Alzheimer's disease (AD) is increasing in frequency as the global population ages. Five drugs are approved for treatment of …
The role of systematic reviews in identifying the limitations of preclinical animal research, 2000-2022: part 1
ReferenceMerel Ritskes-Hoitinga , Pandora Pound Journal of the Royal Society of Medicine. 2022;115(5):186-192. doi: 10.1177/01410768221093551 https://journals.sagepub.com/doi/10.1177/01410768221093551 Keywords animal experimentation Animals Humans Research Design …
New Light on Old Boys: Cognitive and Institutional Particularism in the Peer Review System
ReferenceG.D.L. Travis , Harold Maurice Collins Science, Technology, & Human Values. 1991;16(3):322-341. doi: 10.1177/016224399101600303 Peer review of grant applications, it has been suggested, might be distorted by what is popularly termed old boyism, cronyism, …
Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology
ReferenceLorna Ewart , Athanasia Apostolou , Skyler A. Briggs , Christopher V. Carman , Jake T. Chaff , Anthony R. Heng , Sushma Jadalannagari , Jeshina Janardhanan , Kyung-Jin Jang , Sannidhi R. Joshipura , Mahika M. Kadam , Marianne Kanellias , Ville J. Kujala , …
The preregistration revolution
ReferenceBrian A. Nosek , Charles R. Ebersole , Alexander C. DeHaven , David T. Mellor Proceedings of the National Academy of Sciences. 2018;115(11):2600-2606. doi: 10.1073/pnas.1708274114 Progress in science relies in part on generating hypotheses with existing …
What is open peer review? A systematic review
ReferenceTony Ross-Hellauer F1000Research. 2017;6:588. doi: 10.12688/f1000research.11369.2 Background: “Open peer review” (OPR), despite being a major pillar of Open Science, has neither a standardized definition nor an agreed schema of its features and …
The Science and Value of Diversity: Closing the Gaps in Our Understanding of Inclusion and Diversity
ReferenceTalia H. Swartz , Ann-Gel S. Palermo , Sandra K. Masur , Judith A. Aberg The Journal of Infectious Diseases. 2019;220(S2):S33-S41. doi: 10.1093/infdis/jiz174 Diversity drives excellence. Diversity enhances innovation in biomedical sciences and, as it …