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Medical Journal Peer Review: Process and Bias
ReferenceLaxmaiah Manchikanti , Alan D. Kaye , Mark V. Boswell , Joshua A. Hirsch Pain Physician. 2015;18(1):E1-E14. doi: 10.36076/ppj/2015.18.E1 Scientific peer review is pivotal in health care research in that it facilitates the evaluation of findings for …
Open peer review: A randomised controlled trial
ReferenceElizabeth Walsh , Maeve Rooney , Louis Appleby , Greg Wilkinson The British Journal of Psychiatry. 2018;176(1):47-51. doi: 10.1192/bjp.176.1.47 Background Most scientific journals practise anonymous peer review. There is no evidence, however, that this is …
Three-Dimensional Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2
ReferenceJeonghwan Youk , Taewoo Kim , Kelly V. Evans , Young-Il Jeong , Yongsuk Hur , Seon Pyo Hong , Je Hyoung Kim , Kijong Yi , Su Yeon Kim , Kwon Joong Na , Thomas Bleazard , Ho Min Kim , Mick Fellows , Krishnaa T. Mahbubani , Kourosh Saeb-Parsy , Seon Young …
Is it possible to overcome issues of external validity in preclinical animal research? Why most animal models are bound to fail
ReferencePandora Pound , Merel Ritskes-Hoitinga Journal of Translational Medicine. 2018;16(1):304. doi: 10.1186/s12967-018-1678-1 BACKGROUND: The pharmaceutical industry is in the midst of a productivity crisis and rates of translation from bench to bedside are …
Scientific inertia in animal-based research in biomedicine
ReferenceSimon Lohse Studies in History and Philosophy of Science Part A. 2021;89:41-51. doi: 10.1016/j.shpsa.2021.06.016 Despite aspirations to substitute animal experimentation with alternative methods and recent progress in the area of non-animal approaches, …
Why animal model studies are lost in translation
ReferenceNikolaos G. Frangogiannis The Journal of Cardiovascular Aging. 2022;2(22). doi: 10.20517/jca.2022.10 The development of novel therapies based on understanding the pathophysiologic basis of disease is a major goal of biomedical research. Despite an …
The ability of animal studies to detect serious post marketing adverse events is limited
ReferencePeter J.K. van Meer , Marlous Kooijman , Christine C. Gispen-de Wied , Ellen H.M. Moors , Huub Schellekens Regulatory Toxicology and Pharmacology. 12;64(3):345-349. doi: 10.1016/j.yrtph.2012.09.002 …
Peer Review Bias: A Critical Review
ReferenceSamir Haffar , Fateh Bazerbachi , M. Hassan Murad Mayo Clinic Proceedings. 2019;94(4):670-676. doi: 10.1016/j.mayocp.2018.09.004 Various types of bias and confounding have been described in the biomedical literature that can affect a study before, during, …
Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression
ReferenceCarina Seah , Michael S. Breen , Tom Rusielewicz , Heather N. Bader , Changxin Xu , Christopher J. Hunter , Barry McCarthy , P. J. Michael Deans , Mitali Chattopadhyay , Jordan Goldberg , Frank Desarnaud , Iouri Makotkine , Janine D. Flory , Linda M. …
Tissue Chips and Microphysiological Systems for Disease Modeling and Drug Testing
ReferenceLeslie Donoghue , Khanh T. Nguyen , Caleb Graham , Palaniappan Sethu Micromachines. 2021;12(2):139. doi: 10.3390/mi12020139 Tissue chips (TCs) and microphysiological systems (MPSs) that incorporate human cells are novel platforms to model disease and …