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A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics
ReferenceLonglong Si , Haiqing Bai , Melissa Rodas , Wuji Cao , Crystal Yuri Oh , Amanda Jiang , Rasmus Moller , Daisy Hoagland , Kohei Oishi , Shu Horiuchi , Skyler Uhl , Daniel Blanco-Melo , Randy A. Albrecht , Wen-Chun Liu , Tristan Jordan , Benjamin E. …
A History of Regulatory Animal Testing: What Can We Learn?
ReferenceDoortje Swaters , Anne van Veen , Wim van Meurs , Janette Ellen Turner , Merel Ritskes-Hoitinga Alternatives to Laboratory Animals. 2022;50(5):322-329. doi: 10.1177/02611929221118001 The contemporary pharmaceutical industry is voicing growing concerns …
Reviewer bias in single- versus double-blind peer review
ReferenceAndrew Tomkins , Min Zhang , William D. Heavlin Proceedings of the National Academy of Sciences. 2017;114(48):12708-12713. doi: 10.1073/pnas.1707323114 Peer review may be “single-blind,” in which reviewers are aware of the names and affiliations of paper …
Estimation of clinical trial success rates and related parameters
ReferenceChi Heem Wong , Kien Wei Siah , Andrew W Lo Biostatistics. 2019;20(2):273-286. doi: 10.1093/biostatistics/kxx069 Previous estimates of drug development success rates rely on relatively small samples from databases curated by the pharmaceutical industry …
The perceived feasibility of methods to reduce publication bias
ReferenceHarriet A. Carroll , Zoi Toumpakari , Laura Johnson , James A. Betts PLOS ONE. ;12(10):e0186472. doi: 10.1371/journal.pone.0186472 Publication bias is prevalent within the scientific literature. Whilst there are multiple ideas on how to reduce publication …
Catalogue of bias: publication bias
ReferenceNicholas J. DeVito , Ben Goldacre BMJ Evidence-Based Medicine. 2019;24:53-54. doi: 10.1136/bmjebm-2018-111107 https://ebm.bmj.com/content/24/2/53 Keywords medical ethics Library Collection(s) Bias, peer review, and publishing Download Citation BibTeX …
Modeling Sporadic Alzheimer's Disease in Human Brain Organoids under Serum Exposure
ReferenceXianwei Chen , Guoqiang Sun , E Tian , Mingzi Zhang , Hayk Davtyan , Thomas G. Beach , Eric M. Reiman , Mathew Blurton-Jones , David M. Holtzman , Yanhong Shi Advanced Science. 2021;8(18):2101462. doi: 10.1002/advs.202101462 Alzheimer's disease (AD) is a …
Primary Human Lung Alveolus-on-a-chip Model of Intravascular Thrombosis for Assessment of Therapeutics
ReferenceA. Jain , R. Barrile , A. D. van der Meer , A. Mammoto , T. Mammoto , K. De Ceunynck , O. Aisiku , M. A. Otieno , C. S. Louden , G. A. Hamilton , R. Flaumenhaft , D. E. Ingber Clinical Pharmacology and Therapeutics. 2018;103(2):332-340. doi: …
Human organoids: model systems for human biology and medicine
ReferenceJihoon Kim , Bon-Kyoung Koo , Juergen A. Knoblich Nature Reviews Molecular Cell Biology. 2020;21(10):571-584. doi: 10.1038/s41580-020-0259-3 The historical reliance of biological research on the use of animal models has sometimes made it challenging to …
The Existence of Publication Bias and Risk Factors for Its Occurrence
ReferenceKay Dickersin JAMA. 1990;263(10):1385-1389. doi: 10.1001/jama.1990.03440100097014 Publication bias is the tendency on the parts of investigators, reviewers, and editors to submit or accept manuscripts for publication based on the direction or strength of …