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Where is the evidence that animal research benefits humans?
ReferencePandora Pound , Shah Ebrahim , Peter Sandercock , Michael B Bracken , Ian Roberts BMJ. 2004;328:514-517. doi: 10.1136/bmj.328.7438.514 https://www.bmj.com/lookup/doi/10.1136/bmj.328.7438.514 Library Collection(s) Translation and validation Download …
Robotic fluidic coupling and interrogation of multiple vascularized organ chips
ReferenceRichard Novak , Miles Ingram , Susan Marquez , Debarun Das , Aaron Delahanty , Anna Herland , Ben M. Maoz , Sauveur S. F. Jeanty , Mahadevabharath R. Somayaji , Morgan Burt , Elizabeth Calamari , Angeliki Chalkiadaki , Alexander Cho , Youngjae Choe , …
The Flaws and Human Harms of Animal Experimentation
ReferenceAysha Akhtar Cambridge Quarterly of Healthcare Ethics. 2015;24(4):407-419. doi: 10.1017/S0963180115000079 Nonhuman animal (“animal”) experimentation is typically defended by arguments that it is reliable, that animals provide sufficiently good models of …
Mechanical control of innate immune responses against viral infection revealed in a human lung alveolus chip
ReferenceHaiqing Bai , Longlong Si , Amanda Jiang , Chaitra Belgur , Yunhao Zhai , Roberto Plebani , Crystal Yuri Oh , Melissa Rodas , Aditya Patil , Atiq Nurani , Sarah E. Gilpin , Rani K. Powers , Girija Goyal , Rachelle Prantil-Baun , Donald E. Ingber Nature …
Biomedical Research Must Change - But a Shift Toward Human-specific Research Methods Is Only Part of What Is Needed
ReferenceJarrod Bailey Alternatives to Laboratory Animals. 2021;49(3):69-72. doi: 10.1177/02611929211030417 https://journals.sagepub.com/doi/10.1177/02611929211030417 Keywords Biomedical Research Humans Research Design Library Collection(s) Ethics, policy, and …
Clinical impact of high-profile animal-based research reported in the UK national press
ReferenceJarrod Bailey , Michael Balls BMJ Open Science. 2020;4(1):e100039. doi: 10.1136/bmjos-2019-100039 OBJECTIVES: We evaluated animal-based biomedical 'breakthroughs' reported in the UK national press in 1995 (25 years prior to the conclusion of this study). …
It’s Time to Include Harm to Humans in Harm–Benefit Analysis — But How to Do It, That is the Question
ReferenceMichael Balls Alternatives to Laboratory Animals. 2021;49(5):182-196. doi: 10.1177/02611929211062223 The Three Rs (reduction, refinement, replacement) concept put forward by Russell and Burch now appears to be widely accepted. However, their warnings …
On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology
ReferenceDavid B. Chou , Viktoras Frismantas , Yuka Milton , Rhiannon David , Petar Pop-Damkov , Douglas Ferguson , Alexander MacDonald , Özge Vargel Bölükbaşı , Cailin E. Joyce , Liliana S. Moreira Teixeira , Arianna Rech , Amanda Jiang , Elizabeth Calamari , …
Ectopic Lymphoid Follicle Formation and Human Seasonal Influenza Vaccination Responses Recapitulated in an Organ-on-a-Chip
ReferenceGirija Goyal , Pranav Prabhala , Gautam Mahajan , Bruce Bausk , Tal Gilboa , Liangxia Xie , Yunhao Zhai , Roey Lazarovits , Adam Mansour , Min Sun Kim , Aditya Patil , Danielle Curran , Jaclyn M. Long , Sanjay Sharma , Abidemi Junaid , Limor Cohen , …
Alternative approaches for identifying acute systemic toxicity: Moving from research to regulatory testing
ReferenceJon Hamm , Kristie Sullivan , Amy J. Clippinger , Judy Strickland , Shannon Bell , Barun Bhhatarai , Bas Blaauboer , Warren Casey , David Dorman , Anna Forsby , Natà lia Garcia-Reyero , Sean Gehen , Rabea Graepel , Jon Hotchkiss , Anna Lowit , Joanna …