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Breaking down the barriers to animal-free research
ReferenceLauren Hope , Jarrod Bailey Alternatives to Laboratory Animals. 2025;53(4):215-231. doi: 10.1177/02611929251349465 For centuries, animals have been used in research due to their genetic and physiological similarities to humans. However, significant …
‘Lipstick on a pig’: how to fight back against a peer-review bully
ReferenceKatarina Zimmer Nature. 2025;645(8081):809-812. doi: 10.1038/d41586-025-02922-y Scientific societies, journals, editors and researchers are pushing back against mean-spirited peer reviews. https://www.nature.com/articles/d41586-025-02922-y Keywords …
Threats to grant peer review: a qualitative study
ReferenceJoanie Sims Gould , Anne M. Lasinsky , Adrian Mota , Karim M. Khan , Clare L. Ardern 2025. doi: 10.1136/bmjopen-2024-091666 Background and objectives Peer review is ubiquitous in evaluating scientific research. While peer review of manuscripts submitted …
Decidual Cells Induce Release of Free and Exosome-Bound Interferon Epsilon From Vaginal Epithelial Cells
ReferenceEmmanuel Amabebe , Lauren S. Richardson , Awanit Kumar , Ramkumar Menon , Brandie D. Taylor American Journal of Reproductive Immunology. 2025;94(3):e70129. doi: 10.1111/aji.70129 Problem We tested the hypothesis that oxidative stress (OS)-induced …
Organ-on-a-chip: key industry insights, challenges, and opportunities from 100+ NSF I-Corps interviews
ReferenceRonin-Mae Komarnisky , Shaun Wootten , Nathan Friedman , Mehdi Nikkhah Lab on a Chip. 2025. doi: 10.1039/D5LC00426H Organ-on-a-chip (OoC) is a rapidly advancing technology with significant potential to revolutionize healthcare, drug discovery, and …
Preclinical assessment of pan-influenza A virus CRISPR RNA therapeutics in a human lung alveolus chip
ReferenceYuncheng Man , Ryan R. Posey , Haiqing Bai , Amanda Jiang , Pere Dosta , Diana Ocampo-Alvarado , Roberto Plebani , Jie Ji , Chaitra Belgur , Natalie Artzi , Donald E. Ingber Lab on a Chip. 2025. doi: 10.1039/D5LC00156K CRISPR technology offers an entirely …
Inflammation and epithelial–mesenchymal transition in a CFTR-depleted human bronchial epithelial cell line revealed by proteomics and human organ-on-a-chip
ReferenceDomenico Mattoscio , Luis A. Baeza , Haiqing Bai , Tommaso Colangelo , Simone Castagnozzi , Marta Marzotto , Maria Concetta Cufaro , Virginia Lotti , Yu-Chieh Yuan , Matteo Mucci , Longlong Si , Mariachiara Zuccarini , Maria Tredicine , Simona D'Orazio , …
Assessment of drug permeability using a small airway microphysiological system
ReferenceRobert M. Geiger , Shekh M. Rahman , Md Shadiqur Rashid Roni , Catherine Sullenberger , Sabyasachy Mistry , Katherine Shea , Isra Tariq , Omnia A. Ismaiel , Murali K. Matta , Paula L. Hyland , Sasha Berdichevski , Alexandre J. S. Ribeiro , Ksenia Blinova …
Liver quad culture chip as a model for radiation injury research
ReferenceYuki Ueda , Satoshi Omiya , Jonathan Pinney , Michelle A. Bylicky , Molykutty J. Aryankalayil Scientific Reports. 2025;15(1):12414. doi: 10.1038/s41598-025-96140-1 Both cancer patients receiving radiotherapy and civilians in a mass casualty nuclear event …
Hepatotoxicity evaluation of cannabidiol, cannabinol, cannabichromene and cannabigerol using a human quad culture liver chip
ReferenceJacob D. Larson , Sushma Jadalannagari , Jake Chaff , James Velez , Josiah Sliz , Lorna Ewart , Donna Webster , Jiang Hu Scientific Reports. 2025;15(1):28132. doi: 10.1038/s41598-025-12846-2 Due to the increasing availability of hemp-derived products for …