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New Horizons in Skin Sensitization Assessment of Complex Mixtures: The Use of New Approach Methodologies Beyond Regulatory Approaches
ReferenceArgel Islas-Robles , Meera Ramani , Jakeb Phillips , Gertrude-Emilia Costin Toxics. 2025;13(8):693. doi: 10.3390/toxics13080693 Skin sensitization is a complex biological process induced by a wide range of chemicals, from single molecules to complex …
Comparative analysis of the syncytiotrophoblast in placenta tissue and trophoblast organoids using snRNA sequencing
ReferenceMadeline M Keenen , Liheng Yang , Huan Liang , Veronica J Farmer , Rizban E Worota , Rohit Singh , Amy S Gladfelter , Carolyn B Coyne , Han Zhu , Adèle L Marston eLife. 2025;13:RP101170. doi: 10.7554/eLife.101170 The syncytiotrophoblast (STB) is a …
Artificial intelligence in preclinical research: enhancing digital twins and organ-on-chip to reduce animal testing
ReferenceAmit Gangwal , Antonio Lavecchia Drug Discovery Today. 2025;30(5):104360. doi: 10.1016/j.drudis.2025.104360 Artificial intelligence (AI) is reshaping preclinical drug research offering innovative alternatives to traditional animal testing. Advanced …
Modeling neurotropic virus infection with functional human neural spheroids as a platform for high-throughput antiviral screening and pathogenesis
ReferenceAngelica Medina , Yu-Chi Chen , Jiajing Zhang , Sarah C. Ogden , Samantha Cotsmire , Harshad D. Vishwasrao , Marc Ferrer , Emily M. Lee Antiviral Research. 2025;242:106248. doi: 10.1016/j.antiviral.2025.106248 Neurotropic arboviruses pose significant …
Human neural organoid microphysiological systems show the building blocks necessary for basic learning and memory
ReferenceDowlette-Mary Alam El Din , Leah Moenkemoeller , Alon Loeffler , Forough Habibollahi , Jack Schenkman , Amitav Mitra , Tjitse van der Molen , Lixuan Ding , Jason Laird , Maren Schenke , Erik C. Johnson , Brett J. Kagan , Thomas Hartung , Lena Smirnova …
Modelling metabolic diseases and drug response using stem cells and organoids
ReferenceWenxiang Hu , Mitchell A. Lazar Nature Reviews Endocrinology. 2022;18(12):744-759. doi: 10.1038/s41574-022-00733-z Metabolic diseases, including obesity, diabetes mellitus and cardiovascular disease, are a major threat to health in the modern world, but …
Functional Assays in 3D ObaCell® Fat-on-a-Chip Cultures: Lipolysis and Glucose Uptake Assays
ReferenceKatie Hamel , Emma Rogers , Jeffrey M. Gimble , Trivia Frazier , Cecilia Sanchez Methods in Molecular Biology (Clifton, N.J.). 2024;2783:323-333. doi: 10.1007/978-1-0716-3762-3_23 Advancements in three-dimensional in vitro cultures pose a need for …
Fat-On-A-Chip Models for Research and Discovery in Obesity and Its Metabolic Comorbidities
ReferenceMichelle McCarthy , Theodore Brown , Andrea Alarcon , Christopher Williams , Xiying Wu , Rosalyn D. Abbott , Jeffrey Gimble , Trivia Frazier Tissue Engineering. Part B, Reviews. 2020;26(6):586-595. doi: 10.1089/ten.teb.2019.0261 The obesity epidemic and …
Optimization and validation of a fat-on-a-chip model for non-invasive therapeutic drug discovery
ReferenceLindsey K. Huff , Charles M. Amurgis , Lauren E. Kokai , Rosalyn D. Abbott Frontiers in Bioengineering and Biotechnology. 2024;12. doi: 10.3389/fbioe.2024.1404327 Obesity is a significant public health concern that is closely associated with various …
Publication Pressure vs Research Integrity: Global Insights from an Asian Council of Science Editors Survey
ReferenceMaryam Sayab , Lisa M. DeTora , Muhammad Sarwar Science Editor. 2025;48(2). doi: 10.36591/SE-4803-05 Abstract A survey conducted by the Asian Council of Science Editors (ACSE) investigates how publication metrics may influence academic research integrity. …