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A Vascularized Human Organ Chip Reveals SARS-CoV-2 Susceptibility in Developmentally Guided Tissue Maturation
ReferenceTitilola D. Kalejaiye , Rohan Bhattacharya , Samira Musah Cellular and Molecular Bioengineering. 2025. doi: 10.1007/s12195-025-00851-4 Stem cell-derived models offer traceable cell sources for studying tissue development and disease mechanisms. However, …
Patient-derived esophageal adenocarcinoma organ chip: a physiologically relevant platform for functional precision oncology
ReferenceSanjima Pal , Elee Shimshoni , Salvador Flores Torres , Mingyang Kong , Kulsum Tai , Veena Sangwan , Nicholas Bertos , Swneke Donovan Bailey , Julie Bérubé , Donald E. Ingber , Lorenzo Ferri Journal of Translational Medicine. 2025;23(1):577. doi: …
Non-Financial Conflicts of Interest in Academic Grant Evaluation: A Qualitative Study of Multiple Stakeholders in France
ReferenceHendy Abdoul , Christophe Perrey , Florence Tubach , Philippe Amiel , Isabelle Durand-Zaleski , Corinne Alberti PLOS ONE. ;7(4):e35247. doi: 10.1371/journal.pone.0035247 Background Peer review is the most widely used method for evaluating grant …
HIVIL: A human <i>in vitro</i> inflammatory liver model recapitulates immune-associated drug effects with high predictivity
ReferenceXiaozhong Huang , Yun Ting Soong , Jiahao Wang , Claire Jia Yi Ng , Kartik Mitra , Farah Tasnim , Hanry Yu NAM Journal. 2025;1:100032. doi: 10.1016/j.namjnl.2025.100032 DILI (Drug Induced Liver Injury) is one of leading cause of failure in drug …
Complement-ARIE: Catalyzing the development and adoption of new approach methodologies
ReferenceKristifor Sunderic , Andrew M. Wright , Nicole Kleinstreuer , Victoria Ledbetter , Katelynn A. Milora , Christine Happel , Daniel Shaughnessy , Chariz P. Johnstone , Daniel Anthony Casco , Nikeya Macioce , Jacqui Marzec , Kristin Kano , Margaret J. …
Advancing the 3Rs: innovation, implementation, ethics and society
ReferenceHerwig Grimm , Nikola Biller-Andorno , Thorsten Buch , Maik Dahlhoff , Gail Davies , Christopher R. Cederroth , Otto Maissen , Wilma Lukas , Elisa Passini , Elin Törnqvist , I. Anna S. Olsson , Jenny Sandström Frontiers in Veterinary Science. 2023;10. …
Policy driven changes in animal research practices: mapping researchers’ attitudes towards animal-free innovations using the Netherlands as an example
ReferenceS. Bressers , H. van den Elzen , C. Gräwe , D. van den Oetelaar , P. H. A. Postma , S. K. Schoustra Research Integrity and Peer Review. 2019;4(1):8. doi: 10.1186/s41073-019-0067-5 Reducing the number of animals used in experiments has become a priority …
The UK's Early Access to Medicines Scheme 10 years on: an evaluation using publicly available data
ReferencePandora Pound , Rebecca Ram , Kathy Archibald JRSM Open. 2025;16(2):20542704251317916. doi: 10.1177/20542704251317916 ObjectivesTo investigate the drugs and indications that have passed through the UK's Early Access to Medicines Scheme (EAMS) to date, the …
Necroptosis blockade prevents lung injury in severe influenza
ReferenceAvishekh Gautam , David F. Boyd , Sameer Nikhar , Ting Zhang , Ioannis Siokas , Lee-Ann Van de Velde , Jessica Gaevert , Victoria Meliopoulos , Bikash Thapa , Diego A. Rodriguez , Kathy Q. Cai , Chaoran Yin , Daniel Schnepf , Julius Beer , Carly DeAntoneo …
A survey to evaluate animal methods bias experienced by India-based researchers in the peer review of manuscripts and grant applications
ReferenceSurat Parvatam , Karishma Kaushik , Kasturi Mahadik , Goutami Nayak , Tejaswini Dhurde , Francesca Pistollato , Helder Constantino , Bipasha Gautam , Harshita Mittal , Catharine E. Krebs NAM Journal. 2025:100042. doi: 10.1016/j.namjnl.2025.100042 While …