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A path forward advancing microphysiological systems
ReferenceThomas Hartung , Lena Smirnova ALTEX - Alternatives to animal experimentation. 2025;42(2):183-203. doi: 10.14573/altex.2504091 Microphysiological systems (MPS), including organ-on-chip platforms and complex organoid models, represent a transformative …
Development of a flexible 3D printed TPU-PVC microfluidic devices for organ-on-a-chip applications
ReferenceRodi Kado Abdalkader , Satoshi Konishi , Takuya Fujita Scientific Reports. 2025;15(1):6125. doi: 10.1038/s41598-025-90470-w The development of cost-effective, flexible, and scalable microfluidic devices is crucial for advancing organ-on-a-chip (OoC) …
Asian diversity in human immune cells
ReferenceKian Hong Kock , Le Min Tan , Kyung Yeon Han , Yoshinari Ando , Damita Jevapatarakul , Ankita Chatterjee , Quy Xiao Xuan Lin , Eliora Violain Buyamin , Radhika Sonthalia , Deepa Rajagopalan , Yoshihiko Tomofuji , Shvetha Sankaran , Mi-So Park , Mai Abe , …
From geroscience to precision geromedicine: Understanding and managing aging
ReferenceGuido Kroemer , Andrea B. Maier , Ana Maria Cuervo , Vadim N. Gladyshev , Luigi Ferrucci , Vera Gorbunova , Brian K. Kennedy , Thomas A. Rando , Andrei Seluanov , Felipe Sierra , Eric Verdin , Carlos López-OtÃn Cell. 2025;188(8):2043-2062. doi: …
The translational power of Alzheimer's-based organoid models in personalized medicine: an integrated biological and digital approach embodying patient clinical history
ReferenceCristina Dolciotti , Marco Righi , Eleonora Grecu , Marcello Trucas , Cristina Maxia , Daniela Murtas , Andrea Diana Frontiers in Cellular Neuroscience. 2025;19. doi: 10.3389/fncel.2025.1553642 Alzheimer’s disease (AD) is a complex neurodegenerative …
Multi-zonal liver organoids from human pluripotent stem cells
ReferenceHasan Al Reza , Connie Santangelo , Kentaro Iwasawa , Abid Al Reza , Sachiko Sekiya , Kathryn Glaser , Alexander Bondoc , Jonathan Merola , Takanori Takebe Nature. 2025:1-10. doi: 10.1038/s41586-025-08850-1 Distinct hepatocyte subpopulations are spatially …
Generation of human adult hepatocyte organoids with metabolic functions
ReferenceRyo Igarashi , Mayumi Oda , Ryo Okada , Tomoki Yano , Sirirat Takahashi , Strahil Pastuhov , Mami Matano , Norio Masuda , Kazuhiro Togasaki , Yuki Ohta , Saeko Sato , Takako Hishiki , Makoto Suematsu , Manabu Itoh , Masayuki Fujii , Toshiro Sato Nature. …
Brain organoids: building higher-order complexity and neural circuitry models
ReferenceGulimiheranmu Maisumu , Stephanie Willerth , Michael Nestor , Ben Waldau , Stefan Schülke , Francesco V. Nardi , Osama Ahmed , You Zhou , Madel Durens , Bo Liang , Abraam M. Yakoub Trends in Biotechnology. 2025. doi: 10.1016/j.tibtech.2025.02.009 …
3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels
ReferenceAndrew C. Daly , Matthew D. Davidson , Jason A. Burdick Nature Communications. 2021;12(1):753. doi: 10.1038/s41467-021-21029-2 Cellular models are needed to study human development and disease in vitro, and to screen drugs for toxicity and efficacy. …
Intestinal Organoids for Inflammatory Bowel Disease
ReferenceJianzhen Ren , Silin Huang Frontiers in Cell and Developmental Biology. 2025;13. doi: 10.3389/fcell.2025.1517121 Inflammatory bowel disease (IBD) is a chronic relapsing-remitting immune-mediated disorder affecting the gastrointestinal tract with unknown …