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Limitations of acyclovir and identification of potent HSV antivirals using 3D bioprinted human skin equivalents
ReferenceS. Tori Ellison , Ian Hayman , Kristy Derr , Paige Derr , Shayne Frebert , Zina Itkin , Min Shen , Anthony Jones , Wendy Olson , Lawrence Corey , Anna Wald , Christine Johnston , Youyi Fong , Marc Ferrer , Jia Zhu Nature Communications. 2025;16(1):9200. …
Alternatives to animal testing are the future — it’s time that journals, funders and scientists embrace them
ReferenceTodd J. Herron , Anke Brüning-Richardson , Julie E. Gough , Aline F. Miller , Geoffrey J. Pilkington , John Greenman , Valerie Speirs , Joseph C. Wu Nature. 2025;646(8086):799-801. doi: 10.1038/d41586-025-03344-6 Biomedical research techniques that don’t …
In situ formation and culture of cell spheroids in a low-binding 3D-printed biochip
ReferenceAlexandre Martins , Sylvie Klieber , Charlotte Le Graët , Eric Leclerc , Cécile Legallais , Rachid Jellali Lab on a Chip. 2025. doi: 10.1039/D5LC00503E Organ-on-a-chip and microfluidic systems offer new ways to overcome limitations from traditional in …
Opportunities and insights from pharmaceutical companies on the current use of new approach methodologies in nonclinical safety assessment
ReferenceJacintha Shenton , Imein Bousnina , Michael Oropallo , Rhiannon David , Lucinda Weir , Thomas K. Baker , Helen-Marie Dunmore , Remi Villenave , Mary McElroy , Betty Pettersen , Tushar Kokate , Claudette L. Fuller , Kimberly A. Homan , Eloise Hudry , …
Is regulatory science ready for artificial intelligence?
ReferenceThomas Hartung , Maurice Whelan , Weida Tong , Robert M. Califf npj Digital Medicine. 2025;8(1):1-5. doi: 10.1038/s41746-025-01596-0 Trust is key in AI for regulatory science, but its definition is debated. If AI models use different features yet perform …
Organ-on-Chip: The Future of Nutrition Research in a One Health World
ReferenceManuela Cassotta , Maria Elexpuru-Zabaleta , Sandra Sumalla Cano , Yasmany Armas Diaz , Francesca Giampieri , Zou Xiaobo , Di Zhang , Giuseppe Grosso , Maurizio Battino Food Frontiers. ;n/a(n/a). doi: 10.1002/fft2.70000 The One Health approach emphasizes …
Reviewing Current Guidance for the ‘R’ of Replacement and Rethinking it with the ‘Replacement Checklist’
ReferenceJuliet P. Dukes , Amy Beale , Celean Camp Alternatives to Laboratory Animals. doi: 10.1177/02611929251319265 Research involving the use of animals follows the Three Rs principles of replacement, reduction and refinement. Based on the principle of …
Clinical trials in-a-dish for cardiovascular medicine
ReferenceXuekun Wu , Kyle Swanson , Zehra Yildirim , Wenqiang Liu , Ronglih Liao , Joseph C Wu European Heart Journal. 2024;45(40):4275-4290. doi: 10.1093/eurheartj/ehae519 Cardiovascular diseases persist as a global health challenge that requires methodological …
Human assembloid model of the ascending neural sensory pathway
ReferenceJi-il Kim , Kent Imaizumi , Ovidiu Jurjuț , Kevin W. Kelley , Dong Wang , Mayuri Vijay Thete , Zuzana Hudacova , Neal D. Amin , Rebecca J. Levy , Grégory Scherrer , Sergiu P. Pașca Nature. 2025:1-11. doi: 10.1038/s41586-025-08808-3 Somatosensory pathways …
Biology-inspired dynamic microphysiological system approaches to revolutionize basic research, healthcare and animal welfare
ReferenceUwe Marx , Sonja Beken , Zaozao Chen , Eva-Maria Dehne , Ann Doherty , Lorna Ewart , Suzanne C. Fitzpatrick , Linda G. Griffith , Zhongze Gu , Thomas Hartung , James Hickman , Donald E. Ingber , Seiichi Ishida , Jayoung Jeong , Marcel Leist , Lisa Levin , …