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Creating training opportunities in new approach methodologies for early-career researchers
ReferenceJanine McCarthy , Jarrod Bailey , Ron Baron , Catharine E. Krebs , Mikalah Singer , Elizabeth Baker NAM Journal. 2025;1:100006. doi: 10.1016/j.namjnl.2025.100006 As research and testing methods rapidly advance, there is a pressing need to train the next …
Microphysiological system to address the opioid crisis: A novel multi-organ model of acute opioid overdose and recovery
ReferenceAakash Patel , Suruchi Poddar , Daniel Nierenberg , Stephanie Lang , Hao Wang , Camilly Pestana Pires DeMello , Julio Gamarra , Alisha Colon , Paula Kennedy , Jeffry Roles , Jules Klion , Will Bogen , Christopher Long , Xiufang Guo , Patrick Tighe , …
Advances in cardiac organoid research: implications for cardiovascular disease treatment
ReferenceZiteng Huang , Keran Jia , Yadan Tan , Yang Yu , Wudian Xiao , Xiangyu Zhou , Jingyan Yi , Chunxiang Zhang Cardiovascular Diabetology. 2025;24(1):25. doi: 10.1186/s12933-025-02598-8 Globally, cardiovascular diseases remain among the leading causes of …
Biomedical researchers’ perspectives on the reproducibility of research
ReferenceKelly D. Cobey , Sanam Ebrahimzadeh , Matthew J. Page , Robert T. Thibault , Phi-Yen Nguyen , Farah Abu-Dalfa , David Moher PLOS Biology. ;22(11):e3002870. doi: 10.1371/journal.pbio.3002870 We conducted an international cross-sectional survey of …
Government as the First Investor in Biopharmaceutical Innovation: Evidence From New Drug Approvals 2010–2019
ReferenceEkaterina Galkina Cleary , Matthew J. Jackson , Fred D. Ledley Institute for New Economic Thinking Working Paper Series. 2020:1-72. doi: 10.36687/inetwp133 The discovery and development of new medicines classically involves a linear process of basic …
Using Mice to Model Human Disease: Understanding the Roles of Baseline Housing-Induced and Experimentally Imposed Stresses in Animal Welfare and Experimental Reproducibility
ReferenceBonnie L. Hylander , Elizabeth A. Repasky , Sandra Sexton Animals. 2022;12(3):371. doi: 10.3390/ani12030371 Mice are the most common animal used to study disease, but there are real concerns about the reproducibility of many of these experiments. This …
Advancements in Microphysiological systems: Exploring organoids and organ-on-a-chip technologies in drug development -focus on pharmacokinetics related organs-
ReferenceHiroshi Kimura , Masaki Nishikawa , Naokata Kutsuzawa , Fumiya Tokito , Takuma Kobayashi , Dhimas Agung Kurniawan , Hiroki Shioda , Wenxin Cao , Kenta Shinha , Hiroko Nakamura , Kotaro Doi , Yasuyuki Sakai Drug Metabolism and Pharmacokinetics. …
Rapid and scalable personalized ASO screening in patient-derived organoids
ReferenceJohn C. Means , Anabel L. Martinez-Bengochea , Daniel A. Louiselle , Jacqelyn M. Nemechek , John M. Perry , Emily G. Farrow , Tomi Pastinen , Scott T. Younger Nature. 2025:1-7. doi: 10.1038/s41586-024-08462-1 Personalized antisense oligonucleotides (ASOs) …
The spatial landscape of cancer hallmarks reveals patterns of tumor ecological dynamics and drug sensitivity
ReferenceMustafa Sibai , Sergi Cervilla , Daniela Grases , Eva Musulen , Rossana Lazcano , Chia-Kuei Mo , Veronica Davalos , Arola Fortian , Adrià Bernat , Margarita Romeo , Collin Tokheim , Jordi Barretina , Alexander J. Lazar , Li Ding , Enrique Grande , Teresa …
Human-based complex in vitro models: their promise and potential for rare disease therapeutics
ReferenceSurat Parvatam , Francesca Pistollato , Lindsay J. Marshall , Fabia Furtmann , Devashree Jahagirdar , Mohua Chakraborty Choudhury , Sujata Mohanty , Harshita Mittal , Saveetha Meganathan , Rakesh Mishra Frontiers in Cell and Developmental Biology. …