Search
Adapting an organ-on-chip device to study the effect of fetal sex and maternal race/ethnicity on preterm birth related intraamniotic inflammation leading to fetal neuroinflammation
ReferenceLauren S. Richardson , Nkechinyere Emezienna , Irina Burd , Brandie D. Taylor , Morgan R. Peltier , Arum Han , Ramkumar Menon American Journal of Reproductive Immunology. 2022;88(6):e13638. doi: 10.1111/aji.13638 Problem Fetal neuroinflammation has been …
Toward Inclusivity in Preclinical Drug Development: A Proposition to Start with Intestinal Organoids
ReferenceJulia Y. Co , Jessica A. Klein , Serah Kang , Kimberly A. Homan Advanced Biology. 2023;7(12):2200333. doi: 10.1002/adbi.202200333 Representation of humans from diverse backgrounds in the drug development process is key to advancing health equity, and …
Which experimental factors govern successful animal-to-human translation in multiple sclerosis drug development? A systematic review and meta-analysis
ReferenceIngrid Berg , Pia Härvelid , Wolfgang Emanuel Zürrer , Marianna Rosso , Daniel S. Reich , Benjamin Victor Ineichen eBioMedicine. 2024;110. doi: 10.1016/j.ebiom.2024.105434 …
Comparative analysis of tongue cancer organoids among patients identifies the heritable nature of minimal residual disease
ReferenceMiwako Sase , Taku Sato , Hajime Sato , Fuyuki Miya , Shicheng Zhang , Hiroshi Haeno , Mihoko Kajita , Tadahide Noguchi , Yoshiyuki Mori , Toshiaki Ohteki Developmental Cell. 2024. doi: 10.1016/j.devcel.2024.10.007 The relapse of tongue cancer (TC) after …
Hallmark Molecular and Pathological Features of POLG Disease are Recapitulated in Cerebral Organoids
ReferenceAnbin Chen , Tsering Yangzom , Yu Hong , Bjørn Christian Lundberg , Gareth John Sullivan , Charalampos Tzoulis , Laurence A. Bindoff , Kristina Xiao Liang Advanced Science. 2024;11(18):2307136. doi: 10.1002/advs.202307136 In this research, a 3D brain …
Analysis of animal-to-human translation shows that only 5% of animal-tested therapeutic interventions obtain regulatory approval for human applications
ReferenceBenjamin V. Ineichen , Eva Furrer , Servan L. Grüninger , Wolfgang E. Zürrer , Malcolm R. Macleod PLOS Biology. ;22(6):e3002667. doi: 10.1371/journal.pbio.3002667 There is an ongoing debate about the value of animal experiments to inform medical practice, …
The Significance of Meaning: Why Do Over 90% of Behavioral Neuroscience Results Fail to Translate to Humans, and What Can We Do to Fix It?
ReferenceJoseph P. Garner ILAR Journal. 2014;55(3):438-456. doi: 10.1093/ilar/ilu047 The vast majority of drugs entering human trials fail. This problem (called “attrition”) is widely recognized as a public health crisis, and has been discussed openly for the last …
Sacrificial capillary pumps to engineer multiscalar biological forms
ReferenceSubramanian Sundaram , Joshua H. Lee , Isabel M. Bjørge , Christos Michas , Sudong Kim , Alex Lammers , João F. Mano , Jeroen Eyckmans , Alice E. White , Christopher S. Chen Nature. 2024;636(8042):361-367. doi: 10.1038/s41586-024-08175-5 Natural tissues …
Human respiratory organoids sustained reproducible propagation of human rhinovirus C and elucidation of virus-host interaction
ReferenceCun Li , Yifei Yu , Zhixin Wan , Man Chun Chiu , Jingjing Huang , Shuxin Zhang , Xiaoxin Zhu , Qiaoshuai Lan , Yanlin Deng , Ying Zhou , Wei Xue , Ming Yue , Jian-Piao Cai , Cyril Chik-Yan Yip , Kenneth Kak-Yuen Wong , Xiaojuan Liu , Yang Yu , Lin Huang , …
Advancing pancreatic cancer research and therapeutics: the transformative role of organoid technology
ReferenceJihao Xu , Minh Duc Pham , Vincenzo Corbo , Mariano Ponz-Sarvise , Tobiloba Oni , Daniel Öhlund , Chang-Il Hwang Experimental & Molecular Medicine. 2025:1-9. doi: 10.1038/s12276-024-01378-w Research on pancreatic cancer has transformed with the advent of …