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Transcriptional profile of human thymus reveals IGFBP5 is correlated with age-related thymic involution
ReferenceXiaojing Yang , Xichan Chen , Wei Wang , Siming Qu , Binbin Lai , Ji Zhang , Jian Chen , Chao Han , Yi Tian , Yingbin Xiao , Weiwu Gao , Yuzhang Wu Frontiers in Immunology. 2024;15. doi: 10.3389/fimmu.2024.1322214 Thymus is the main immune organ which …
Omicron subvariants illustrate reduced respiratory tissue penetration, cell damage and inflammatory responses in human airway epithelia
ReferenceViktoria Zaderer , Hussam Abd El Halim , Anna-Lena Wyremblewsky , Gaia Lupoli , Christopher Dächert , Maximilian Muenchhoff , Alexander Graf , Helmut Blum , Cornelia Lass-Flörl , Oliver T. Keppler , Lukas A. Huber , Wilfried Posch , Doris Wilflingseder …
The application of natural language processing for the extraction of mechanistic information in toxicology
ReferenceMarie Corradi , Thomas Luechtefeld , Alyanne M. de Haan , Raymond Pieters , Jonathan H. Freedman , Tamara Vanhaecke , Mathieu Vinken , Marc Teunis Frontiers in Toxicology. 2024;6. doi: 10.3389/ftox.2024.1393662 To study the ways in which compounds can …
Brain Chimeroids reveal individual susceptibility to neurotoxic triggers
ReferenceNoelia Antón-Bolaños , Irene Faravelli , Tyler Faits , Sophia Andreadis , Rahel Kastli , Sebastiano Trattaro , Xian Adiconis , Anqi Wei , Abhishek Sampath Kumar , Daniela J. Di Bella , Matthew Tegtmeyer , Ralda Nehme , Joshua Z. Levin , Aviv Regev , Paola …
Integrated multimodal cell atlas of Alzheimer’s disease
ReferenceMariano I. Gabitto , Kyle J. Travaglini , Victoria M. Rachleff , Eitan S. Kaplan , Brian Long , Jeanelle Ariza , Yi Ding , Joseph T. Mahoney , Nick Dee , Jeff Goldy , Erica J. Melief , Anamika Agrawal , Omar Kana , Xingjian Zhen , Samuel T. Barlow , …
Manipulating immune activity of macrophages: a materials and mechanics perspective
ReferenceAbigail J. Clevenger , Aakanksha Jha , Erika Moore , Shreya A. Raghavan Trends in Biotechnology. 2024. doi: 10.1016/j.tibtech.2024.07.009 https://www.cell.com/trends/biotechnology/abstract/S0167-7799(24)00187-2 Keywords engineering approaches in vitro …
Exploring animal methods bias in biomedical research funding: Workshop proceedings and action steps
ReferenceCatharine E. Krebs , Sven Geissler , Kathrin Herrmann , Kenneth Kandaras , Owen Kavanagh , Laura M. Langan , Francesca Pistollato , Sandeep Raha , Ignacio J. Tripodi , Emily R. Trunnell NAM Journal. 2025;1:100004. doi: 10.1016/j.namjnl.2024.100004 New …
Repetitive injury induces phenotypes associated with Alzheimer’s disease by reactivating HSV-1 in a human brain tissue model
ReferenceDana M. Cairns , Brooke M. Smiley , Jordan A. Smiley , Yasaman Khorsandian , Marilyn Kelly , Ruth F. Itzhaki , David L. Kaplan Science Signaling. 2025;18(868):eado6430. doi: 10.1126/scisignal.ado6430 Infection with herpes simplex virus type 1 (HSV-1) in …
Open peer review, pros and cons from the perspective of an early career researcher
ReferenceTania Henriquez mBio. ;14(5):e01948-23. doi: 10.1128/mbio.01948-23 Peer review is considered by many to be a fundamental component of scientific publishing. In this context, open peer review (OPR) has gained popularity in recent years as a tool to …
Greater genetic diversity is needed in human pluripotent stem cell models
ReferenceSulagna Ghosh , Ralda Nehme , Lindy E. Barrett Nature Communications. 2022;13(1):7301. doi: 10.1038/s41467-022-34940-z While there are a growing number of human pluripotent stem cell repositories, genetic diversity remains limited in most collections and …