An organ-chip model of sporadic ALS using iPSC-derived spinal cord motor neurons and an integrated blood-brain-like barrier

Deepti Lall, Michael J. Workman, Samuel Sances, Briana N. Ondatje, Shaughn Bell, George Lawless, Amanda Woodbury, Dylan West, Amanda Meyer, Andrea Matlock, Vineet Vaibhav, Jennifer E. Van Eyk, Clive N. Svendsen

Cell Stem Cell. 2025;32(7):1139-1153.e7. doi: 10.1016/j.stem.2025.05.015

https://www.cell.com/cell-stem-cell/abstract/S1934-5909(25)00222-X

Keywords

amyotrophic lateral sclerosis

glutamatergic synapse

microfluidic organ-chips

motor neuron identity

neuronal maturation

synaptic signaling

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