Nervous system

Sneha B. Rao, Zhixiong Sun, Francesco Brundu, et al. Aberrant pace of cortical neuron development in brain organoids from patients with 22q11.2 deletion syndrome-associated schizophrenia. Nature Communications. 2025;16(1):6986. doi:10.1038/s41467-025-62187-x

Deepti Lall, Michael J. Workman, Samuel Sances, et al. An organ-chip model of sporadic ALS using iPSC-derived spinal cord motor neurons and an integrated blood-brain-like barrier. Cell Stem Cell. 2025;32(7):1139-1153.e7. doi:10.1016/j.stem.2025.05.015

Dowlette-Mary Alam El Din, Leah Moenkemoeller, Alon Loeffler, et al. Human neural organoid microphysiological systems show the building blocks necessary for basic learning and memory. Communications Biology. 2025;8(1):1237. doi:10.1038/s42003-025-08632-5

Dana M. Cairns, Brooke M. Smiley, Jordan A. Smiley, et al. Repetitive injury induces phenotypes associated with Alzheimer’s disease by reactivating HSV-1 in a human brain tissue model. Science Signaling. 2025;18(868):eado6430. doi:10.1126/scisignal.ado6430

Aakash Patel, Suruchi Poddar, Daniel Nierenberg, et al. Microphysiological system to address the opioid crisis: A novel multi-organ model of acute opioid overdose and recovery. Current Research in Toxicology. 2025;8:100209. doi:10.1016/j.crtox.2024.100209

Xianwei Chen, Guoqiang Sun, Lizhao Feng, E. Tian, Yanhong Shi. Human iPSC-derived microglial cells protect neurons from neurodegeneration in long-term cultured adhesion brain organoids. Communications Biology. 2025;8(1):1-11. doi:10.1038/s42003-024-07401-0

Anna Pagliaro, Francesco Andreatta, Roxy Finger, Benedetta Artegiani, Delilah Hendriks. Generation of human fetal brain organoids and their CRISPR engineering for brain tumor modeling. Nature Protocols. 2025:1-38. doi:10.1038/s41596-024-01107-7

Anna Pagliaro, Francesco Andreatta, Roxy Finger, Benedetta Artegiani, Delilah Hendriks. Generation of human fetal brain organoids and their CRISPR engineering for brain tumor modeling. Nature Protocols. 2025:1-38. doi:10.1038/s41596-024-01107-7

Kai Cheng, Anannya Kshirsagar, John Nixon, et al. Model systems for emulating human tissue and physiology in psychiatric research. Frontiers in Neuroscience. 2025;19:1527826. doi:10.3389/fnins.2025.1527826

Ji-il Kim, Kent Imaizumi, Ovidiu Jurjuț, et al. Human assembloid model of the ascending neural sensory pathway. Nature. 2025:1-11. doi:10.1038/s41586-025-08808-3