Nervous system

Dana M. Cairns, Brooke M. Smiley, Jordan A. Smiley, et al. Repetitive injury induces phenotypes associated with Alzheimer’s disease by reactivating HSV-1 in a human brain tissue model. Science Signaling. 2025;18(868):eado6430. doi:10.1126/scisignal.ado6430

Aakash Patel, Suruchi Poddar, Daniel Nierenberg, et al. Microphysiological system to address the opioid crisis: A novel multi-organ model of acute opioid overdose and recovery. Current Research in Toxicology. 2025;8:100209. doi:10.1016/j.crtox.2024.100209

Xianwei Chen, Guoqiang Sun, Lizhao Feng, E. Tian, Yanhong Shi. Human iPSC-derived microglial cells protect neurons from neurodegeneration in long-term cultured adhesion brain organoids. Communications Biology. 2025;8(1):1-11. doi:10.1038/s42003-024-07401-0

Anna Pagliaro, Francesco Andreatta, Roxy Finger, Benedetta Artegiani, Delilah Hendriks. Generation of human fetal brain organoids and their CRISPR engineering for brain tumor modeling. Nature Protocols. 2025:1-38. doi:10.1038/s41596-024-01107-7

Anna Pagliaro, Francesco Andreatta, Roxy Finger, Benedetta Artegiani, Delilah Hendriks. Generation of human fetal brain organoids and their CRISPR engineering for brain tumor modeling. Nature Protocols. 2025:1-38. doi:10.1038/s41596-024-01107-7

Kai Cheng, Anannya Kshirsagar, John Nixon, et al. Model systems for emulating human tissue and physiology in psychiatric research. Frontiers in Neuroscience. 2025;19:1527826. doi:10.3389/fnins.2025.1527826

Ji-il Kim, Kent Imaizumi, Ovidiu Jurjuț, et al. Human assembloid model of the ascending neural sensory pathway. Nature. 2025:1-11. doi:10.1038/s41586-025-08808-3

Gulimiheranmu Maisumu, Stephanie Willerth, Michael Nestor, et al. Brain organoids: building higher-order complexity and neural circuitry models. Trends in Biotechnology. 2025. doi:10.1016/j.tibtech.2025.02.009

Jakub Scaber, Iona Thomas-Wright, Alex J. Clark, et al. Cellular and axonal transport phenotypes due to the C9ORF72 HRE in iPSC motor and sensory neurons. Stem Cell Reports. 2024;19(7):957-972. doi:10.1016/j.stemcr.2024.05.008

Neal D. Amin, Kevin W. Kelley, Konstantin Kaganovsky, et al. Generating human neural diversity with a multiplexed morphogen screen in organoids. Cell Stem Cell. 2024;31(12):1831-1846.e9. doi:10.1016/j.stem.2024.10.016