Nervous system

Benedetta Frizzi, Adriana Margarida Barbosa Correia, Irene Faravelli, Ludo Van Den Bosch, Stefania Corti. Using human 3D organoid models to gain mechanistic insight in motor neuron diseases. Nature Reviews Neuroscience. 2026:1-21. doi:10.1038/s41583-026-01057-x

Vukasin M. Jovanovic, Narisu Narisu, Lori L. Bonnycastle, et al. Scalable hypothalamic neuron differentiation from human pluripotent stem cells suitable for modeling metabolic disorders. Stem Cell Reports. 2026. doi:10.1016/j.stemcr.2026.102958

George M. Gibbons, Tanja Fuchsberger, Mai Abdelgawad, et al. A human corticospinal organoid-slice connectoid model informs enhancer strategies for post-injury axon regrowth. Cell Reports. 2026;45(6). doi:10.1016/j.celrep.2026.117399

Seungmi Ryu, Jason Inman, Hyenjong Hong, et al. Modeling Friedreich’s ataxia with Bergmann glia-enriched human cerebellar organoids. Communications Biology. 2026. doi:10.1038/s42003-026-10180-5

Barbara Pavan, Giada Botti, Alessandro Dalpiaz, Raffaello Sbordoni, Abdullah Talari, Valon Llabjani. A new microphysiological platform to study the permeation of neuroactive agents across intestinal and brain barriers. Biofabrication. 2026;18(2):025013. doi:10.1088/1758-5090/ae514c

Tatsuya Osaki, Chloe Delepine, Yuma Osako, et al. Early differential impact of MeCP2 mutations on functional networks in Rett syndrome patient-derived human cortical organoids. Nature Communications. 2026. doi:10.1038/s41467-026-71458-0

Anannya Kshirsagar, Hayk Mnatsakanyan, Sai Kulkarni, et al. Multi-Region Brain Organoids Integrating Cerebral, Mid-Hindbrain, and Endothelial Systems. Advanced Science. 2025;12(33):e03768. doi:10.1002/advs.202503768

Laura Castro-Aldrete, Melanie Einsiedler, Carla Cuní-López, et al. Modelling sex differences of neurological disorders in vitro. Nature Reviews Bioengineering. 2025:1-22. doi:10.1038/s44222-025-00355-w

Kai Cheng, Autumn Williams, Anannya Kshirsagar, et al. Machine learning-enabled detection of electrophysiological signatures in iPSC-derived models of schizophrenia and bipolar disorder. APL Bioengineering. 2025;9(3):036118. doi:10.1063/5.0250559

Dowlette-Mary Alam El Din, Leah Moenkemoeller, Alon Loeffler, et al. Human neural organoid microphysiological systems show the building blocks necessary for basic learning and memory. Communications Biology. 2025;8(1):1237. doi:10.1038/s42003-025-08632-5