Nervous system

Sneha B. Rao, Zhixiong Sun, Francesco Brundu, et al. Aberrant pace of cortical neuron development in brain organoids from patients with 22q11.2 deletion syndrome-associated schizophrenia. Nature Communications. 2025;16(1):6986. doi:10.1038/s41467-025-62187-x

Deepti Lall, Michael J. Workman, Samuel Sances, et al. An organ-chip model of sporadic ALS using iPSC-derived spinal cord motor neurons and an integrated blood-brain-like barrier. Cell Stem Cell. 2025;32(7):1139-1153.e7. doi:10.1016/j.stem.2025.05.015

Dowlette-Mary Alam El Din, Leah Moenkemoeller, Alon Loeffler, et al. Human neural organoid microphysiological systems show the building blocks necessary for basic learning and memory. Communications Biology. 2025;8(1):1237. doi:10.1038/s42003-025-08632-5

Dowlette-Mary Alam El Din, Leah Moenkemoeller, Alon Loeffler, et al. Human neural organoid microphysiological systems show the building blocks necessary for basic learning and memory. Communications Biology. 2025;8(1):1237. doi:10.1038/s42003-025-08632-5

Kai Cheng, Autumn Williams, Anannya Kshirsagar, et al. Machine learning-enabled detection of electrophysiological signatures in iPSC-derived models of schizophrenia and bipolar disorder. APL Bioengineering. 2025;9(3):036118. doi:10.1063/5.0250559

Adrià Casamitjana, Matteo Mancini, Eleanor Robinson, et al. A probabilistic histological atlas of the human brain for MRI segmentation. Nature. 2025:1-8. doi:10.1038/s41586-025-09708-2

Irene Faravelli, Noelia Antón-Bolaños, Juliana R. Brown, Paola Arlotta. Brain Organoids: Tools for Understanding the Uniqueness and Individual Variability of the Human Brain. Annual Review of Genomics and Human Genetics. 2025;26(Volume 26, 2025):299-320. doi:10.1146/annurev-genom-111522-014009

Alex Rittenhouse, Caroline Krall, Jesse Plotkin, et al. Microglia-containing neural organoids as brain microphysiological systems for long-term culture. Frontiers in Cellular Neuroscience. 2025;19. doi:10.3389/fncel.2025.1616470

Carlos Serna, Bhavya Bhardwaj, Tromondae K. Feaster, Ksenia Blinova. Nonclinical human neural new approach methodologies (NAMs): Electrophysiological assessment of opioid agonist and antagonist combination. NAM Journal. 2025;1:100064. doi:10.1016/j.namjnl.2025.100064

Kaveena Autar, Xiufang Guo, Haley Powell, et al. Developing a functional non-animal CNS stress model utilizing long-term potentiation with human iPSC-cortical neurons to evaluate therapeutics. Biomedicine & Pharmacotherapy. 2025;192:118556. doi:10.1016/j.biopha.2025.118556