Nervous system

Alex Rittenhouse, Caroline Krall, Jesse Plotkin, et al. Microglia-containing neural organoids as brain microphysiological systems for long-term culture. Frontiers in Cellular Neuroscience. 2025;19. doi:10.3389/fncel.2025.1616470

Irene Faravelli, Noelia Antón-Bolaños, Juliana R. Brown, Paola Arlotta. Brain Organoids: Tools for Understanding the Uniqueness and Individual Variability of the Human Brain. Annual Review of Genomics and Human Genetics. 2025;26(Volume 26, 2025):299-320. doi:10.1146/annurev-genom-111522-014009

Catarina M. Gomes, Daniel Simão, Carolina Cardoso Gonçalves, et al. Addressing neuroinflammation in human induced pluripotent stem cell-derived central nervous system neurospheroids. iScience. 2025;28(9). doi:10.1016/j.isci.2025.113246

Alexander G. Bury, Alicja Olejnik, Chiara Tocco, et al. Investigating the ageing-Parkinson’s disease nexus: standardisation of in vitro models and techniques by the PD-AGE network. npj Parkinson’s Disease. 2025;11(1):289. doi:10.1038/s41531-025-01137-2

Laura Castro-Aldrete, Melanie Einsiedler, Carla Cuní-López, et al. Modelling sex differences of neurological disorders in vitro. Nature Reviews Bioengineering. 2025:1-22. doi:10.1038/s44222-025-00355-w

Alice E. Stanton, Adele Bubnys, Emre Agbas, et al. Engineered 3D immuno-glial-neurovascular human miBrain model. Proceedings of the National Academy of Sciences. 2025;122(42):e2511596122. doi:10.1073/pnas.2511596122

Hyehyun Kim, Gregory Girardi, Allison Pickle, Testaverde S. Kim, Erkin Seker. Microfluidic tools to model, monitor, and modulate the gut–brain axis. Biomicrofluidics. 2025;19(2):021301. doi:10.1063/5.0253041

Anannya Kshirsagar, Hayk Mnatsakanyan, Sai Kulkarni, et al. Multi-Region Brain Organoids Integrating Cerebral, Mid-Hindbrain, and Endothelial Systems. Advanced Science. 2025;12(33):e03768. doi:10.1002/advs.202503768

Alexander Atamian, Marcella Birtele, Negar Hosseini, et al. Human cerebellar organoids with functional Purkinje cells. Cell Stem Cell. 2024;31(1):39-51.e6. doi:10.1016/j.stem.2023.11.013

Xufeng Xue, Yung Su Kim, Alfredo-Isaac Ponce-Arias, et al. A patterned human neural tube model using microfluidic gradients. Nature. 2024;628:391-399. doi:10.1038/s41586-024-07204-7