Building trust in the integration of artificial intelligence into chemical risk assessment: findings from the 2024 ECETOC workshop

Archives of Toxicology. 2026. doi: 10.1007/s00204-025-04286-8

Artificial Intelligence (AI) is increasingly influencing chemical risk assessment, enabling faster, more comprehensive, and potentially more ethical assessments. The application of AI in chemical risk assessment refers to both generative and predictive algorithms encompassing machine learning, to analyse complex chemical, biological, and environmental data and provide insights into adverse effect potential for humans and ecosystems. AI systems support the prediction of chemical hazards, exposure levels, and adverse effects by learning from experimental results, mechanistic models, and regulatory datasets, thereby enhancing the efficiency of safety evaluations.

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