Toxicology

K. Taylor, R. Ram, L. Ewart, et al. Perspective: How complex in vitro models are addressing the challenges of predicting drug-induced liver injury. Frontiers in Drug Discovery. 2025;5. doi:10.3389/fddsv.2025.1536756

Eike Cöllen, Kristina Bartmann, Jonathan Blum, et al. Mapping out strategies to further develop human-relevant, new approach methodology (NAM)-based developmental neurotoxicity (DNT) testing. ALTEX - Alternatives to animal experimentation. 2025. doi:10.14573/altex.2501091

Monica Piergiovanni, Milena Mennecozzi, Erio Barale-Thomas, et al. Bridging imaging-based in vitro methods from biomedical research to regulatory toxicology. Archives of Toxicology. 2025. doi:10.1007/s00204-024-03922-z

Katja Graf, José Martin Murrieta-Coxca, Tobias Vogt, et al. Digital twin-enhanced three-organ microphysiological system for studying drug pharmacokinetics in pregnant women. Frontiers in Pharmacology. 2025;16. doi:10.3389/fphar.2025.1528748

Andrew S. Robertson, Nahid Latif, Imein Bousnina, et al. Accelerating adoption of new approach methodologies in regulatory decision making: an industry perspective. Nature Reviews Drug Discovery. 2025. doi:10.1038/d41573-025-00038-6

Xiaozhong Huang, Yun Ting Soong, Jiahao Wang, et al. HIVIL: A human <i>in vitro</i> inflammatory liver model recapitulates immune-associated drug effects with high predictivity. NAM Journal. 2025;1:100032. doi:10.1016/j.namjnl.2025.100032

Shivangi Shrimali, Minjun Chen, Dongying Li, Weida Tong. New approach methodologies (NAMs) for drug-induced liver injury (DILI): Where are we now?. Drug Discovery Today. 2025:104452. doi:10.1016/j.drudis.2025.104452

Argel Islas-Robles, Meera Ramani, Jakeb Phillips, Gertrude-Emilia Costin. New Horizons in Skin Sensitization Assessment of Complex Mixtures: The Use of New Approach Methodologies Beyond Regulatory Approaches. Toxics. 2025;13(8):693. doi:10.3390/toxics13080693

Noelia Antón-Bolaños, Irene Faravelli, Tyler Faits, et al. Brain Chimeroids reveal individual susceptibility to neurotoxic triggers. Nature. 2024;631(8019):142-149. doi:10.1038/s41586-024-07578-8

Marie Corradi, Thomas Luechtefeld, Alyanne M. de Haan, et al. The application of natural language processing for the extraction of mechanistic information in toxicology. Frontiers in Toxicology. 2024;6. doi:10.3389/ftox.2024.1393662