Humans

Else Driehuis, Kai Kretzschmar, Hans Clevers. Establishment of patient-derived cancer organoids for drug-screening applications. Nature Protocols. 2020;15(10):3380-3409. doi:10.1038/s41596-020-0379-4

Ehsanollah Moradi, Sasan Jalili-Firoozinezhad, Mehran Solati-Hashjin. Microfluidic organ-on-a-chip models of human liver tissue. Acta Biomaterialia. 2020;116:67-83. doi:10.1016/j.actbio.2020.08.041

Frans Schutgens, Hans Clevers. Human Organoids: Tools for Understanding Biology and Treating Diseases. Annual Review of Pathology. 2020;15:211-234. doi:10.1146/annurev-pathmechdis-012419-032611

Vanessa Monteil, Hyesoo Kwon, Patricia Prado, et al. Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2. Cell. 2020;181(4):905-913.e7. doi:10.1016/j.cell.2020.04.004

Fjodor A. Yousef Yengej, Jitske Jansen, Maarten B. Rookmaaker, Marianne C. Verhaar, Hans Clevers. Kidney Organoids and Tubuloids. Cells. 2020;9(6):1326. doi:10.3390/cells9061326

Huaqi Tang, Yasmine Abouleila, Longlong Si, et al. Human Organs-on-Chips for Virology. Trends in Microbiology. 2020;28(11):934-946. doi:10.1016/j.tim.2020.06.005

Jennifer M. Rosenbluth, Ron C. J. Schackmann, G. Kenneth Gray, et al. Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages. Nature Communications. 2020;11(1):1711. doi:10.1038/s41467-020-15548-7

Laura Pellegrini, Anna Albecka, Donna L. Mallery, et al. SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids. Cell Stem Cell. 2020;27(6):951-961.e5. doi:10.1016/j.stem.2020.10.001

Eric Vallabh Minikel, Konrad J. Karczewski, Hilary C. Martin, et al. Evaluating drug targets through human loss-of-function genetic variation. Nature. 2020;581(7809):459-464. doi:10.1038/s41586-020-2267-z

Mart M. Lamers, Joep Beumer, Jelte van der Vaart, et al. SARS-CoV-2 productively infects human gut enterocytes. Science (New York, N.Y.). 2020;369(6499):50-54. doi:10.1126/science.abc1669