Drug Discovery

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Alice Maria Giani, Shuibing Chen. Human pluripotent stem cell-based organoids and cell platforms for modelling SARS-CoV-2 infection and drug discovery. Stem Cell Research. 2021;53:102207. doi:10.1016/j.scr.2021.102207
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Patrick M. Misun, Burçak Yesildag, Felix Forschler, et al. In Vitro Platform for Studying Human Insulin Release Dynamics of Single Pancreatic Islet Microtissues at High Resolution. Advanced Biosystems. 2020;4(3):e1900291. doi:10.1002/adbi.201900291
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Jun-Hwan Yoo, Mark Donowitz. Intestinal enteroids/organoids: A novel platform for drug discovery in inflammatory bowel diseases. World Journal of Gastroenterology. 2019;25(30):4125-4147. doi:10.3748/wjg.v25.i30.4125
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A. Jain, R. Barrile, A. D. van der Meer, et al. Primary Human Lung Alveolus-on-a-chip Model of Intravascular Thrombosis for Assessment of Therapeutics. Clinical Pharmacology and Therapeutics. 2018;103(2):332-340. doi:10.1002/cpt.742
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Janet Piñero, Laura I. Furlong, Ferran Sanz. In silico models in drug development: where we are. Current Opinion in Pharmacology. 2018;42:111-121. doi:10.1016/j.coph.2018.08.007
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Kathy Archibald, Katya Tsaioun, J. Gerry Kenna, Pandora Pound. Better science for safer medicines: the human imperative. Journal of the Royal Society of Medicine. 2018;111(12):433-438. doi:10.1177/0141076818812783
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Ben G. Fitzpatrick, Elena Koustova, Yun Wang. Getting personal with the “reproducibility crisis”: interviews in the animal research community. Lab Animal. 2018;47(7):175-177. doi:10.1038/s41684-018-0088-6
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Dorothée Diogo, Chao Tian, Christopher S. Franklin, et al. Phenome-wide association studies across large population cohorts support drug target validation. Nature Communications. 2018;9(1):4285. doi:10.1038/s41467-018-06540-3
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William G. Kaelin. Common pitfalls in preclinical cancer target validation. Nature Reviews. Cancer. 2017;17(7):425-440. doi:10.1038/nrc.2017.32
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Eric W. Esch, Anthony Bahinski, Dongeun Huh. Organs-on-chips at the frontiers of drug discovery. Nature Reviews Drug Discovery. 2015;14(4):248-260. doi:10.1038/nrd4539
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