Drug Discovery

Ashley L. Eadie, Holly Fernandez Lynch, Naomi Scheinerman, Ravi B. Parikh. Advancing FDA New Approach Methodologies from animal models through digital twins. npj Digital Medicine. 2026. doi:10.1038/s41746-026-02476-x

Kang Zhang, Xin Yang, Yifei Wang, et al. Artificial intelligence in drug development. Nature Medicine. 2025;31(1):45-59. doi:10.1038/s41591-024-03434-4

Ramila E. Gulieva, Parvaneh Ahmadvand, Benjamin S. Freedman. A novel rapalog shows improved safety vs. efficacy in a human organoid model of polycystic kidney disease. Stem Cell Reports. 2025;20(2). doi:10.1016/j.stemcr.2024.102395

Todd J. Herron, Anke Brüning-Richardson, Julie E. Gough, et al. Alternatives to animal testing are the future — it’s time that journals, funders and scientists embrace them. Nature. 2025;646(8086):799-801. doi:10.1038/d41586-025-03344-6

Ruth A. Roberts, Mamta Behl, Helena T. Hogberg, et al. Use of new approach methodologies (NAMs) in epilepsy research and seizure risk assessment. Drug Discovery Today. 2025;31(1):104569. doi:10.1016/j.drudis.2025.104569

Hae-Ran Park, Yeongkag Kwon, Hyun Jung Ji, et al. A human lung organoid platform for studying radiation-induced pulmonary fibrosis and antifibrotic drug screening. Scientific Reports. 2025. doi:10.1038/s41598-025-31582-1

Tomoki Imaoka, Reiko Onuki-Nagasaki, Hiroshi Kimura, et al. Development of a novel gut microphysiological system that facilitates assessment of drug absorption kinetics in gut. Scientific Reports. 2024;14(1):29921. doi:10.1038/s41598-024-80946-6

Jonas Cerneckis, Guojun Bu, Yanhong Shi. Pushing the boundaries of brain organoids to study Alzheimer’s disease. Trends in Molecular Medicine. 2023;29(8):659-672. doi:10.1016/j.molmed.2023.05.007

Rizwan Qureshi, Muhammad Irfan, Taimoor Muzaffar Gondal, et al. AI in drug discovery and its clinical relevance. Heliyon. 2023;9(7). doi:10.1016/j.heliyon.2023.e17575

Stephen Burgess, Amy M. Mason, Andrew J. Grant, et al. Using genetic association data to guide drug discovery and development: Review of methods and applications. American Journal of Human Genetics. 2023;110(2):195-214. doi:10.1016/j.ajhg.2022.12.017