Drug Discovery

Todd J. Herron, Anke Brüning-Richardson, Julie E. Gough, et al. Alternatives to animal testing are the future — it’s time that journals, funders and scientists embrace them. Nature. 2025;646(8086):799-801. doi:10.1038/d41586-025-03344-6

Ramila E. Gulieva, Parvaneh Ahmadvand, Benjamin S. Freedman. A novel rapalog shows improved safety vs. efficacy in a human organoid model of polycystic kidney disease. Stem Cell Reports. 2025;20(2). doi:10.1016/j.stemcr.2024.102395

Tomoki Imaoka, Reiko Onuki-Nagasaki, Hiroshi Kimura, et al. Development of a novel gut microphysiological system that facilitates assessment of drug absorption kinetics in gut. Scientific Reports. 2024;14(1):29921. doi:10.1038/s41598-024-80946-6

Jonas Cerneckis, Guojun Bu, Yanhong Shi. Pushing the boundaries of brain organoids to study Alzheimer’s disease. Trends in Molecular Medicine. 2023;29(8):659-672. doi:10.1016/j.molmed.2023.05.007

Stephen Burgess, Amy M. Mason, Andrew J. Grant, et al. Using genetic association data to guide drug discovery and development: Review of methods and applications. American Journal of Human Genetics. 2023;110(2):195-214. doi:10.1016/j.ajhg.2022.12.017

Rizwan Qureshi, Muhammad Irfan, Taimoor Muzaffar Gondal, et al. AI in drug discovery and its clinical relevance. Heliyon. 2023;9(7). doi:10.1016/j.heliyon.2023.e17575

Michael Eisenstein. Organoids open fresh paths to biomedical advances. Nature. 2022;612(7940):S34-S35. doi:10.1038/d41586-022-04214-1

Lorna Ewart, Athanasia Apostolou, Skyler A. Briggs, et al. Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology. Communications Medicine. 2022;2:154. doi:10.1038/s43856-022-00209-1

Manuela Cassotta, Hugo Geerts, Lise Harbom, et al. The future of Parkinson’s disease research: A new paradigm of human-specific investigation is necessary… and possible. ALTEX. 2022;39(4):694-709. doi:10.14573/altex.2203161

Hubert Dirven, Gunn E. Vist, Sricharan Bandhakavi, et al. Performance of preclinical models in predicting drug-induced liver injury in humans: a systematic review. Scientific Reports. 2021;11(1):6403. doi:10.1038/s41598-021-85708-2