Translation and validation

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Dean G. Brown, Heike J. Wobst, Abhijeet Kapoor, Leslie A. Kenna, Noel Southall. Clinical development times for innovative drugs. Nature Reviews Drug Discovery. 2021;21(11):793-794. doi:10.1038/d41573-021-00190-9
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Donald E. Ingber. Is it Time for Reviewer 3 to Request Human Organ Chip Experiments Instead of Animal Validation Studies? Advanced Science. 2020;7(22):2002030. doi:10.1002/advs.202002030
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Michael M. Webster, Christian Rutz. How STRANGE are your study animals? Nature. 2020;582:337-340. doi:10.1038/d41586-020-01751-5
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S. Vincent Rajkumar. The high cost of prescription drugs: causes and solutions. Blood Cancer Journal. 2020;10(6):71. doi:10.1038/s41408-020-0338-x
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Antje Schmidt-Pogoda, Nadine Bonberg, Mailin Hannah Marie Koecke, et al. Why Most Acute Stroke Studies Are Positive in Animals but Not in Patients: A Systematic Comparison of Preclinical, Early Phase, and Phase 3 Clinical Trials of Neuroprotective Agents. Annals of Neurology. 2020;87(1):40-51. doi:10.1002/ana.25643
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Merel Ritskes-Hoitinga, Cathalijn Leenaars, Wouter Beumer, Tineke Coenen-de Roo, Frans Stafleu, Franck L. B. Meijboom. Improving Translation by Identifying Evidence for More Human-Relevant Preclinical Strategies. Animals: an open access journal from MDPI. 2020;10(7):1170. doi:10.3390/ani10071170
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Johnique T. Atkins, Goldy C. George, Kenneth Hess, et al. Pre-clinical animal models are poor predictors of human toxicities in phase 1 oncology clinical trials. British Journal of Cancer. 2020;123(10):1496-1501. doi:10.1038/s41416-020-01033-x
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Jarrod Bailey, Michael Balls. Clinical impact of high-profile animal-based research reported in the UK national press. BMJ Open Science. 2020;4(1):e100039. doi:10.1136/bmjos-2019-100039
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Rachel L. C. Barrett, Matthew Dawson, Tim B. Dyrby, et al. Differences in Frontal Network Anatomy Across Primate Species. Journal of Neuroscience. 2020;40(10):2094-2107. doi:10.1523/JNEUROSCI.1650-18.2019
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Pandora Pound, Merel Ritskes-Hoitinga. Can prospective systematic reviews of animal studies improve clinical translation? Journal of Translational Medicine. 2020;18:15. doi:10.1186/s12967-019-02205-x
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