Translation and validation

Olivier J. Wouters, Martin McKee, Jeroen Luyten. Estimated Research and Development Investment Needed to Bring a New Medicine to Market, 2009-2018. JAMA. 2020;323(9):844-853. doi:10.1001/jama.2020.1166

Michael M. Webster, Christian Rutz. How STRANGE are your study animals? Nature. 2020;582:337-340. doi:10.1038/d41586-020-01751-5

Donald E. Ingber. Is it Time for Reviewer 3 to Request Human Organ Chip Experiments Instead of Animal Validation Studies? Advanced Science. 2020;7(22):2002030. doi:10.1002/advs.202002030

S. Vincent Rajkumar. The high cost of prescription drugs: causes and solutions. Blood Cancer Journal. 2020;10(6):71. doi:10.1038/s41408-020-0338-x

Antje Schmidt-Pogoda, Nadine Bonberg, Mailin Hannah Marie Koecke, et al. Why Most Acute Stroke Studies Are Positive in Animals but Not in Patients: A Systematic Comparison of Preclinical, Early Phase, and Phase 3 Clinical Trials of Neuroprotective Agents. Annals of Neurology. 2020;87(1):40-51. doi:10.1002/ana.25643

Rachel L. C. Barrett, Matthew Dawson, Tim B. Dyrby, et al. Differences in Frontal Network Anatomy Across Primate Species. Journal of Neuroscience. 2020;40(10):2094-2107. doi:10.1523/JNEUROSCI.1650-18.2019

Jarrod Bailey, Michael Balls. Clinical impact of high-profile animal-based research reported in the UK national press. BMJ Open Science. 2020;4(1):e100039. doi:10.1136/bmjos-2019-100039

Pandora Pound, Merel Ritskes-Hoitinga. Can prospective systematic reviews of animal studies improve clinical translation? Journal of Translational Medicine. 2020;18:15. doi:10.1186/s12967-019-02205-x

Stanley T. Parish, Michael Aschner, Warren Casey, et al. An evaluation framework for new approach methodologies (NAMs) for human health safety assessment. Regulatory Toxicology and Pharmacology. 2020;112:104592. doi:10.1016/j.yrtph.2020.104592

Pandora Pound. Are Animal Models Needed to Discover, Develop and Test Pharmaceutical Drugs for Humans in the 21st Century? Animals (Basel). 2020;10(12):2455. doi:10.3390/ani10122455