Toxicology

Andreas O Stucki, Monita Sharma, Jessica R Murray, et al. Human in vitro airway models to assess point-of-contact respiratory toxicity of surfactants and derive human equivalent concentrations after single dose exposure. Toxicological Sciences. 2026:kfag118. doi:10.1093/toxsci/kfag118

Julen Sanz-Serrano, Laura Suter-Dick. Hepatotoxicity: Mechanisms and animal-free prediction models. Toxicology. 2026:154400. doi:10.1016/j.tox.2026.154400

Andreas Natsch, Peter Griem, Amaia Irizar, et al. Derivation of a Point of Departure using NAMs for application in Quantitative Risk Assessment of fragrance materials. Regulatory Toxicology and Pharmacology. 2026:106052. doi:10.1016/j.yrtph.2026.106052

Elisabet Berggren, Andrew P. Worth. Managing change while phasing out animal testing in chemical safety assessments – a collection of stakeholder experiences and expectations. NAM Journal. 2026;2:100079. doi:10.1016/j.namjnl.2026.100079

Timothy W. Gant, Alistair Boxall, Daniel Burgwinkel, et al. Building trust in the integration of artificial intelligence into chemical risk assessment: findings from the 2024 ECETOC workshop. Archives of Toxicology. 2026. doi:10.1007/s00204-025-04286-8

Yanning Hao, Nakissa Sadrieh. FDA CDER analysis of non-human primate (NHP) data in monoclonal antibody (mAb) development to support the streamlining of nonclinical safety studies. Regulatory Toxicology and Pharmacology. 2026;170:106124. doi:10.1016/j.yrtph.2026.106124

Maria Christou, Anastasia Georgantzopoulou, Maria Hultman, et al. The rise of new approach methodologies (NAMs) for environmental safety assessment of chemicals: A systematic review of the current status, challenges and strategies for broader adoption of NAMs. NAM Journal. 2026;2:100115. doi:10.1016/j.namjnl.2026.100115

Agnes L. Karmaus, Anna L. Kreutz, Oluwakemi Oyetade, et al. Perspectives on variability of in vivo toxicology studies: considerations for next-generation toxicology. Frontiers in Toxicology. 2026;8. doi:10.3389/ftox.2026.1778353

Jacob D. Larson, Sushma Jadalannagari, Jake Chaff, et al. Hepatotoxicity evaluation of cannabidiol, cannabinol, cannabichromene and cannabigerol using a human quad culture liver chip. Scientific Reports. 2025;15(1):28132. doi:10.1038/s41598-025-12846-2

Shivangi Shrimali, Minjun Chen, Dongying Li, Weida Tong. New approach methodologies (NAMs) for drug-induced liver injury (DILI): Where are we now? Drug Discovery Today. 2025;30(9):104452. doi:10.1016/j.drudis.2025.104452