Toxicology

Yanning Hao, Nakissa Sadrieh. FDA CDER analysis of non-human primate (NHP) data in monoclonal antibody (mAb) development to support the streamlining of nonclinical safety studies. Regulatory Toxicology and Pharmacology. 2026;170:106124. doi:10.1016/j.yrtph.2026.106124

Agnes L. Karmaus, Anna L. Kreutz, Oluwakemi Oyetade, et al. Perspectives on variability of in vivo toxicology studies: considerations for next-generation toxicology. Frontiers in Toxicology. 2026;8. doi:10.3389/ftox.2026.1778353

Timothy W. Gant, Alistair Boxall, Daniel Burgwinkel, et al. Building trust in the integration of artificial intelligence into chemical risk assessment: findings from the 2024 ECETOC workshop. Archives of Toxicology. 2026. doi:10.1007/s00204-025-04286-8

Elisabet Berggren, Andrew P. Worth. Managing change while phasing out animal testing in chemical safety assessments – a collection of stakeholder experiences and expectations. NAM Journal. 2026;2:100079. doi:10.1016/j.namjnl.2026.100079

Andreas Natsch, Peter Griem, Amaia Irizar, et al. Derivation of a Point of Departure using NAMs for application in Quantitative Risk Assessment of fragrance materials. Regulatory Toxicology and Pharmacology. 2026:106052. doi:10.1016/j.yrtph.2026.106052

Julen Sanz-Serrano, Laura Suter-Dick. Hepatotoxicity: Mechanisms and animal-free prediction models. Toxicology. 2026:154400. doi:10.1016/j.tox.2026.154400

Argel Islas-Robles, Meera Ramani, Jakeb Phillips, Gertrude-Emilia Costin. New Horizons in Skin Sensitization Assessment of Complex Mixtures: The Use of New Approach Methodologies Beyond Regulatory Approaches. Toxics. 2025;13(8):693. doi:10.3390/toxics13080693

Katja Graf, José Martin Murrieta-Coxca, Tobias Vogt, et al. Digital twin-enhanced three-organ microphysiological system for studying drug pharmacokinetics in pregnant women. Frontiers in Pharmacology. 2025;16. doi:10.3389/fphar.2025.1528748

Robert M. Geiger, Shekh M. Rahman, Md Shadiqur Rashid Roni, et al. Assessment of drug permeability using a small airway microphysiological system. Frontiers in Pharmacology. 2025;16. doi:10.3389/fphar.2025.1621775

Jacob D. Larson, Sushma Jadalannagari, Jake Chaff, et al. Hepatotoxicity evaluation of cannabidiol, cannabinol, cannabichromene and cannabigerol using a human quad culture liver chip. Scientific Reports. 2025;15(1):28132. doi:10.1038/s41598-025-12846-2