1.
Chunhui Tian, Zheng Ao, Jonas Cerneckis, et al. Understanding monocyte-driven neuroinflammation in Alzheimer’s disease using human cortical organoid microphysiological systems. Science Advances. 2025;11(34):eadu2708. doi:10.1126/sciadv.adu2708
Nervous system
1.
Tjitse van der Molen, Alex Spaeth, Mattia Chini, et al. Preconfigured neuronal firing sequences in human brain organoids. Nature Neuroscience. 2025:1-13. doi:10.1038/s41593-025-02111-0
1.
Kai Cheng, Autumn Williams, Anannya Kshirsagar, et al. Machine learning-enabled detection of electrophysiological signatures in iPSC-derived models of schizophrenia and bipolar disorder. APL Bioengineering. 2025;9(3):036118. doi:10.1063/5.0250559
1.
Christopher R. Bye, Elizabeth Qian, Katherine Lim, et al. Large-scale drug screening in iPSC-derived motor neurons from sporadic ALS patients identifies a potential combinatorial therapy. Nature Neuroscience. 2025:1-13. doi:10.1038/s41593-025-02118-7
1.
Alice E. Stanton, Adele Bubnys, Emre Agbas, et al. Engineered 3D immuno-glial-neurovascular human miBrain model. Proceedings of the National Academy of Sciences. 2025;122(42):e2511596122. doi:10.1073/pnas.2511596122
1.
Simona Lange, Martin Ebeling, Athéna Loye, et al. Human myelinated brain organoids with integrated microglia as a model for myelin repair and remyelinating therapies. Science Translational Medicine. 2025;17(815):eadp7047. doi:10.1126/scitranslmed.adp7047
1.
Lena Smirnova, Thomas Hartung. The Promise and Potential of Brain Organoids. Advanced Healthcare Materials. 2024;13(21):2302745. doi:10.1002/adhm.202302745
1.
Mariano I. Gabitto, Kyle J. Travaglini, Victoria M. Rachleff, et al. Integrated multimodal cell atlas of Alzheimer’s disease. Nature Neuroscience. 2024;27(12):2366-2383. doi:10.1038/s41593-024-01774-5
1.
Alexander Atamian, Marcella Birtele, Negar Hosseini, Giorgia Quadrato. Generation and long-term culture of human cerebellar organoids from pluripotent stem cells. Nature Protocols. 2024:1-32. doi:10.1038/s41596-024-01093-w
1.
Marcella Birtele, Madeline Lancaster, Giorgia Quadrato. Modelling human brain development and disease with organoids. Nature Reviews Molecular Cell Biology. 2024:1-24. doi:10.1038/s41580-024-00804-1