Nervous system

Catarina M. Gomes, Daniel Simão, Carolina Cardoso Gonçalves, et al. Addressing neuroinflammation in human induced pluripotent stem cell-derived central nervous system neurospheroids. iScience. 2025;28(9). doi:10.1016/j.isci.2025.113246

Kaveena Autar, Xiufang Guo, Haley Powell, et al. Developing a functional non-animal CNS stress model utilizing long-term potentiation with human iPSC-cortical neurons to evaluate therapeutics. Biomedicine & Pharmacotherapy. 2025;192:118556. doi:10.1016/j.biopha.2025.118556

Alexander G. Bury, Alicja Olejnik, Chiara Tocco, et al. Investigating the ageing-Parkinson’s disease nexus: standardisation of in vitro models and techniques by the PD-AGE network. npj Parkinson’s Disease. 2025;11(1):289. doi:10.1038/s41531-025-01137-2

Alice E. Stanton, Adele Bubnys, Emre Agbas, et al. Engineered 3D immuno-glial-neurovascular human miBrain model. Proceedings of the National Academy of Sciences. 2025;122(42):e2511596122. doi:10.1073/pnas.2511596122

Anannya Kshirsagar, Hayk Mnatsakanyan, Sai Kulkarni, et al. Multi-Region Brain Organoids Integrating Cerebral, Mid-Hindbrain, and Endothelial Systems. Advanced Science. 2025;12(33):e03768. doi:10.1002/advs.202503768

Hyehyun Kim, Gregory Girardi, Allison Pickle, Testaverde S. Kim, Erkin Seker. Microfluidic tools to model, monitor, and modulate the gut–brain axis. Biomicrofluidics. 2025;19(2):021301. doi:10.1063/5.0253041

Chunhui Tian, Zheng Ao, Jonas Cerneckis, et al. Understanding monocyte-driven neuroinflammation in Alzheimer’s disease using human cortical organoid microphysiological systems. Science Advances. 2025;11(34):eadu2708. doi:10.1126/sciadv.adu2708

Judit González-Gallego, Katalin Todorov-Völgyi, Stephan A. Müller, et al. A fully iPS-cell-derived 3D model of the human blood–brain barrier for exploring neurovascular disease mechanisms and therapeutic interventions. Nature Neuroscience. 2025:1-14. doi:10.1038/s41593-025-02123-w

Isabel Turpin-Moreno, Adriana Modrego, Andrea Martí-Sarrias, et al. Variability vs. phenotype: Multimodal analysis of Dravet syndrome brain organoids powered by deep learning. iScience. 2025;28(11). doi:10.1016/j.isci.2025.113831

James G. Shamul, Zhiyuan Wang, Hyeyeon Gong, et al. Meta-analysis of the make-up and properties of in vitro models of the healthy and diseased blood–brain barrier. Nature Biomedical Engineering. 2025;9(4):566-598. doi:10.1038/s41551-024-01250-2