Nervous system

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Jamie Cowley, Neale Harrison, Ashley Pegg, et al. P2X7 receptor-mediated IL-1β release by human brain tissue: the impact of CNS-penetrant potential therapeutics. Brain. 2026;149(10):3614-3630. doi:10.1093/brain/awag068
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Jiuhong Nan, Carles A. Boix, Shaohui Shi, et al. Single-cell profiling and genetic regulation of alternative polyadenylation in the human brain. Nature Genetics. 2026:1-13. doi:10.1038/s41588-026-02758-w
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Song Qu, Yue Wu, Pu Sun, Cui Song, Yanyan Wang. A patient-specific induced pluripotent stem cell and neural stem cell resource for angelman syndrome with 15q11.2-q13 deletion. Scientific Reports. 2026;16(1):27002. doi:10.1038/s41598-026-57826-2
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Carina Maranga, Adriana A. Vieira, João Camões dos Santos, et al. Stem-cell modeling of cerebellar dysfunction of Angelman syndrome. Communications Biology. 2026. doi:10.1038/s42003-026-11008-y
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Kristel N. Eigenhuis, Roberto Montoro Ferrer, R. Jeroen Pasterkamp. Neural Organoid Models as a Platform for Studying Disease Mechanisms in Amyotrophic Lateral Sclerosis. Journal of Neurochemistry. 2026;170(7):e70513. doi:10.1111/jnc.70513
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Pramod Bharadwaj Chandrashekar, Sayali Anil Alatkar, Noah Cohen Kalafut, et al. Personalized single-cell transcriptomics reveals molecular diversity in Alzheimer’s disease. Nature Communications. 2026;17(1):9596. doi:10.1038/s41467-026-72310-1
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Chenfeng He, Athan Z. Li, Kalpana Hanthanan Arachchilage, et al. AI-based characterization of Alzheimer’s disease phenotypes from population-scale single-cell data. Nature Medicine. 2026:1-13. doi:10.1038/s41591-025-04128-1
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Sanan Venkatesh, Roman Kosoy, Zhenyi Wu, et al. Single-nucleus transcriptome-wide association study of human brain disorders. Nature. 2026;657(8133):1016-1026. doi:10.1038/s41586-026-10836-6
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Irene Faravelli, Noelia Antón-Bolaños, Anqi Wei, et al. Human brain organoids record the passage of time over multiple years. Nature. 2026:1-11. doi:10.1038/s41586-026-10877-x
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Donghoon Lee, Mikaela Koutrouli, Nicolas Y. Masse, et al. Single-cell atlas of transcriptomic vulnerability across brain disorders. Nature. 2026;657(8133):988-1002. doi:10.1038/s41586-025-09573-z
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