Nervous system

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Sanan Venkatesh, Roman Kosoy, Zhenyi Wu, et al. Single-nucleus transcriptome-wide association study of human brain disorders. Nature. 2026;657(8133):1016-1026. doi:10.1038/s41586-026-10836-6
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Claudia V. Nguyen, Antoni Martija, Daniel C. Jaklic, et al. Thalamic NRXN1-mediated input to human cortical progenitors drives excitatory neurogenesis. Science. 2026;393(6815):eady5180. doi:10.1126/science.ady5180
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Carlos Serna, Bhavya Bhardwaj, Tromondae K. Feaster, Ksenia Blinova. Nonclinical human neural new approach methodologies (NAMs): Electrophysiological assessment of opioid agonist and antagonist combination. NAM Journal. 2025;1:100064. doi:10.1016/j.namjnl.2025.100064
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Kai Cheng, Autumn Williams, Anannya Kshirsagar, et al. Machine learning-enabled detection of electrophysiological signatures in iPSC-derived models of schizophrenia and bipolar disorder. APL Bioengineering. 2025;9(3):036118. doi:10.1063/5.0250559
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Alex Rittenhouse, Caroline Krall, Jesse Plotkin, et al. Microglia-containing neural organoids as brain microphysiological systems for long-term culture. Frontiers in Cellular Neuroscience. 2025;19. doi:10.3389/fncel.2025.1616470
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Catarina M. Gomes, Daniel Simão, Carolina Cardoso Gonçalves, et al. Addressing neuroinflammation in human induced pluripotent stem cell-derived central nervous system neurospheroids. iScience. 2025;28(9). doi:10.1016/j.isci.2025.113246
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Kaveena Autar, Xiufang Guo, Haley Powell, et al. Developing a functional non-animal CNS stress model utilizing long-term potentiation with human iPSC-cortical neurons to evaluate therapeutics. Biomedicine & Pharmacotherapy. 2025;192:118556. doi:10.1016/j.biopha.2025.118556
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Irene Faravelli, Noelia Antón-Bolaños, Juliana R. Brown, Paola Arlotta. Brain Organoids: Tools for Understanding the Uniqueness and Individual Variability of the Human Brain. Annual Review of Genomics and Human Genetics. 2025;26(Volume 26, 2025):299-320. doi:10.1146/annurev-genom-111522-014009
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Gulimiheranmu Maisumu, Stephanie Willerth, Michael Nestor, et al. Brain organoids: building higher-order complexity and neural circuitry models. Trends in Biotechnology. 2025. doi:10.1016/j.tibtech.2025.02.009
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Hyehyun Kim, Gregory Girardi, Allison Pickle, Testaverde S. Kim, Erkin Seker. Microfluidic tools to model, monitor, and modulate the gut–brain axis. Biomicrofluidics. 2025;19(2):021301. doi:10.1063/5.0253041
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