Nervous system

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Tatsuya Osaki, Chloe Delepine, Yuma Osako, et al. Early differential impact of MeCP2 mutations on functional networks in Rett syndrome patient-derived human cortical organoids. Nature Communications. 2026. doi:10.1038/s41467-026-71458-0
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Julien Klimmt, Carolina Cardoso Gonçalves, Jessica Valentina Montgomery, et al. A reproducible three-dimensional model of human brain tissue to investigate physiological and disease-associated microglia phenotypes. Nature Neuroscience. 2026:1-17. doi:10.1038/s41593-026-02367-0
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Benedetta Frizzi, Adriana Margarida Barbosa Correia, Irene Faravelli, Ludo Van Den Bosch, Stefania Corti. Using human 3D organoid models to gain mechanistic insight in motor neuron diseases. Nature Reviews Neuroscience. 2026:1-21. doi:10.1038/s41583-026-01057-x
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Vukasin M. Jovanovic, Narisu Narisu, Lori L. Bonnycastle, et al. Scalable hypothalamic neuron differentiation from human pluripotent stem cells suitable for modeling metabolic disorders. Stem Cell Reports. 2026. doi:10.1016/j.stemcr.2026.102958
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George M. Gibbons, Tanja Fuchsberger, Mai Abdelgawad, et al. A human corticospinal organoid-slice connectoid model informs enhancer strategies for post-injury axon regrowth. Cell Reports. 2026;45(6). doi:10.1016/j.celrep.2026.117399
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Seungmi Ryu, Jason Inman, Hyenjong Hong, et al. Modeling Friedreich’s ataxia with Bergmann glia-enriched human cerebellar organoids. Communications Biology. 2026. doi:10.1038/s42003-026-10180-5
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Miguel F. Tenreiro, Alysson R. Muotri. Reconstructing human corticogenesis: Insights from cerebral organoids into neurodevelopment and disease modeling. Developmental Cell. 2026:S1534-5807(26)00083. doi:10.1016/j.devcel.2026.02.018
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Kai Cheng, Autumn Williams, Anannya Kshirsagar, et al. Machine learning-enabled detection of electrophysiological signatures in iPSC-derived models of schizophrenia and bipolar disorder. APL Bioengineering. 2025;9(3):036118. doi:10.1063/5.0250559
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Anannya Kshirsagar, Hayk Mnatsakanyan, Sai Kulkarni, et al. Multi-Region Brain Organoids Integrating Cerebral, Mid-Hindbrain, and Endothelial Systems. Advanced Science. 2025;12(33):e03768. doi:10.1002/advs.202503768
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Dowlette-Mary Alam El Din, Leah Moenkemoeller, Alon Loeffler, et al. Human neural organoid microphysiological systems show the building blocks necessary for basic learning and memory. Communications Biology. 2025;8(1):1237. doi:10.1038/s42003-025-08632-5
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