Nervous system

Barbara Pavan, Giada Botti, Alessandro Dalpiaz, Raffaello Sbordoni, Abdullah Talari, Valon Llabjani. A new microphysiological platform to study the permeation of neuroactive agents across intestinal and brain barriers. Biofabrication. 2026;18(2):025013. doi:10.1088/1758-5090/ae514c

Miguel F. Tenreiro, Alysson R. Muotri. Reconstructing human corticogenesis: Insights from cerebral organoids into neurodevelopment and disease modeling. Developmental Cell. 2026:S1534-5807(26)00083. doi:10.1016/j.devcel.2026.02.018

Tatsuya Osaki, Chloe Delepine, Yuma Osako, et al. Early differential impact of MeCP2 mutations on functional networks in Rett syndrome patient-derived human cortical organoids. Nature Communications. 2026. doi:10.1038/s41467-026-71458-0

Seungmi Ryu, Jason Inman, Hyenjong Hong, et al. Modeling Friedreich’s ataxia with Bergmann glia-enriched human cerebellar organoids. Communications Biology. 2026. doi:10.1038/s42003-026-10180-5

George M. Gibbons, Tanja Fuchsberger, Mai Abdelgawad, et al. A human corticospinal organoid-slice connectoid model informs enhancer strategies for post-injury axon regrowth. Cell Reports. 2026;45(6). doi:10.1016/j.celrep.2026.117399

Vukasin M. Jovanovic, Narisu Narisu, Lori L. Bonnycastle, et al. Scalable hypothalamic neuron differentiation from human pluripotent stem cells suitable for modeling metabolic disorders. Stem Cell Reports. 2026. doi:10.1016/j.stemcr.2026.102958

Benedetta Frizzi, Adriana Margarida Barbosa Correia, Irene Faravelli, Ludo Van Den Bosch, Stefania Corti. Using human 3D organoid models to gain mechanistic insight in motor neuron diseases. Nature Reviews Neuroscience. 2026:1-21. doi:10.1038/s41583-026-01057-x

Julien Klimmt, Carolina Cardoso Gonçalves, Jessica Valentina Montgomery, et al. A reproducible three-dimensional model of human brain tissue to investigate physiological and disease-associated microglia phenotypes. Nature Neuroscience. 2026:1-17. doi:10.1038/s41593-026-02367-0

Pramod Bharadwaj Chandrashekar, Sayali Anil Alatkar, Noah Cohen Kalafut, et al. Personalized single-cell transcriptomics reveals molecular diversity in Alzheimer’s disease. Nature Communications. 2026;17(1):9596. doi:10.1038/s41467-026-72310-1

Carina Maranga, Adriana A. Vieira, João Camões dos Santos, et al. Stem-cell modeling of cerebellar dysfunction of Angelman syndrome. Communications Biology. 2026. doi:10.1038/s42003-026-11008-y