Nervous system

Alexander G. Bury, Alicja Olejnik, Chiara Tocco, et al. Investigating the ageing-Parkinson’s disease nexus: standardisation of in vitro models and techniques by the PD-AGE network. npj Parkinson’s Disease. 2025;11(1):289. doi:10.1038/s41531-025-01137-2

Kaveena Autar, Xiufang Guo, Haley Powell, et al. Developing a functional non-animal CNS stress model utilizing long-term potentiation with human iPSC-cortical neurons to evaluate therapeutics. Biomedicine & Pharmacotherapy. 2025;192:118556. doi:10.1016/j.biopha.2025.118556

Catarina M. Gomes, Daniel Simão, Carolina Cardoso Gonçalves, et al. Addressing neuroinflammation in human induced pluripotent stem cell-derived central nervous system neurospheroids. iScience. 2025;28(9). doi:10.1016/j.isci.2025.113246

Kai Cheng, Autumn Williams, Anannya Kshirsagar, et al. Machine learning-enabled detection of electrophysiological signatures in iPSC-derived models of schizophrenia and bipolar disorder. APL Bioengineering. 2025;9(3):036118. doi:10.1063/5.0250559

Dowlette-Mary Alam El Din, Leah Moenkemoeller, Alon Loeffler, et al. Human neural organoid microphysiological systems show the building blocks necessary for basic learning and memory. Communications Biology. 2025;8(1):1237. doi:10.1038/s42003-025-08632-5

Deepti Lall, Michael J. Workman, Samuel Sances, et al. An organ-chip model of sporadic ALS using iPSC-derived spinal cord motor neurons and an integrated blood-brain-like barrier. Cell Stem Cell. 2025;32(7):1139-1153.e7. doi:10.1016/j.stem.2025.05.015

Aakash Patel, Suruchi Poddar, Daniel Nierenberg, et al. Microphysiological system to address the opioid crisis: A novel multi-organ model of acute opioid overdose and recovery. Current Research in Toxicology. 2025;8:100209. doi:10.1016/j.crtox.2024.100209

Anna Pagliaro, Francesco Andreatta, Roxy Finger, Benedetta Artegiani, Delilah Hendriks. Generation of human fetal brain organoids and their CRISPR engineering for brain tumor modeling. Nature Protocols. 2025:1-38. doi:10.1038/s41596-024-01107-7

Xianwei Chen, Guoqiang Sun, Lizhao Feng, E. Tian, Yanhong Shi. Human iPSC-derived microglial cells protect neurons from neurodegeneration in long-term cultured adhesion brain organoids. Communications Biology. 2025;8(1):1-11. doi:10.1038/s42003-024-07401-0

Anna Pagliaro, Francesco Andreatta, Roxy Finger, Benedetta Artegiani, Delilah Hendriks. Generation of human fetal brain organoids and their CRISPR engineering for brain tumor modeling. Nature Protocols. 2025:1-38. doi:10.1038/s41596-024-01107-7