Ethics, policy, and legislation

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Jesse Weidema, Martine de Vries, Christine Mummery, Nienke de Graeff. The ethical aspects of human organ-on-chip models: A mapping review. Stem Cell Reports. 2025;20(11). doi:10.1016/j.stemcr.2025.102686
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Jessica Rosolowski, Tilo Weber, Atena Malakpour-Permlid, Stina Oredsson. Revisiting 3Rs: rethinking replacement and new approach methodologies. Frontiers in Toxicology. 2025;7. doi:10.3389/ftox.2025.1664209
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Angela Bearth, Birgit Kopainsky, Lowenna B. Jones, et al. Exploring experiences of the regulatory toxicology system: system-level promoters and inhibitors of new approach methodologies. Archives of Toxicology. 2025;99(12):4909-4930. doi:10.1007/s00204-025-04168-z
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Jean Knight, Costanza Rovida, Kate Willett, Jay Ingram. Fish count, too – The animal toll of REACH aquatic toxicity tests. ALTEX - Alternatives to animal experimentation. 2025. doi:10.14573/altex.2506011
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Francesca Pistollato, Fabia Furtmann, Annalisa Gastaldello, et al. Bridging the prevention gap: funding distribution and methodological shifts in prevention-focused biomedical research under EU framework programmes. Journal of Translational Medicine. 2025;23(1):1006. doi:10.1186/s12967-025-07019-8
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Pandora Pound. A sociological perspective on the challenges of displacing animal research within academia: the contribution of Bourdieu. NAM Journal. 2025;1:100057. doi:10.1016/j.namjnl.2025.100057
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Angela Bearth, Nicolas Roth, Tom Jansen, et al. New approach methodologies in human health risk assessment across European regulatory frameworks: Status quo, barriers and drivers for regulatory acceptance and use. Environment International. 2025;196:109279. doi:10.1016/j.envint.2025.109279
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Maximilian Andreas Storz, Elizabeth Dean. Status of animal experimentation in nutrition and dietetic research: Policies of 100 leading journals and new approach methodologies. Accountability in Research. 2025;32(8):1545-1563. doi:10.1080/08989621.2024.2398104
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Sarah A Carratt, Christina L Zuch de Zafra, Elias Oziolor, et al. An industry perspective on the FDA Modernization Act 2.0/3.0: potential next steps for sponsors to reduce animal use in drug development. Toxicological Sciences. 2025;203(1):28-34. doi:10.1093/toxsci/kfae122
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John J. Pippin, Jarrod Bailey, Mark Kennedy, et al. Institutional animal care and use committees and the challenges of evaluating animal research proposals. Research Integrity and Peer Review. 2025;10(1):11. doi:10.1186/s41073-025-00169-9
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