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Advanced In Vitro Three-Dimensional Skin Models of Atopic Dermatitis
ReferenceHye-Jeong Jang , Jung Bok Lee , Jeong-Kee Yoon Tissue Engineering and Regenerative Medicine. 2023;20(4):539-552. doi: 10.1007/s13770-023-00532-1 Atopic dermatitis (AD) is one of the most prevalent inflammatory skin diseases that is characterized by …
Advances in the Biofabrication of 3D Skin in vitro: Healthy and Pathological Models
ReferenceMatthew J. Randall , Astrid Jüngel , Markus Rimann , Karin Wuertz-Kozak Frontiers in Bioengineering and Biotechnology. 2018;6. doi: 10.3389/fbioe.2018.00154 The relevance for in vitro three-dimensional (3D) tissue culture of skin has …
An innervated skin 3D in vitro model for dermatological research
ReferenceEmma Rousi , Afonso Malheiro , Abhishek Harichandan , Ronny Mohren , Ana Filipa Lourenço , Carlos Mota , Berta Cillero-Pastor , Paul Wieringa , Lorenzo Moroni In vitro models. 2023;2(3):113-121. doi: 10.1007/s44164-022-00021-0 A 3D in vitro model of …
The 21st Century movement within the area of skin sensitization assessment: From the animal context towards current human-relevant <i>in vitro</i> solutions
ReferenceRenato Ivan de Ávila , Malin Lindstedt , Marize Campos Valadares Regulatory Toxicology and Pharmacology. 2019;108:104445. doi: 10.1016/j.yrtph.2019.104445 In a regulatory context, skin sensitization hazard and risk evaluations of manufactured products and …
In vitro testing strategy for assessing the skin sensitizing potential of “difficult to test” cosmetic ingredients
ReferenceMathilde Bergal , Mickaël Puginier , Cédric Gerbeix , Hervé Groux , Alicia Roso , Françoise Cottrez , Alain Milius Toxicology in Vitro. 2020;65:104781. doi: 10.1016/j.tiv.2020.104781 Before placing a new cosmetic ingredient on the market, manufacturers …
Recent efforts to elucidate the scientific validity of animal-based drug tests by the pharmaceutical industry, pro-testing lobby groups, and animal welfare organisations
ReferenceJarrod Bailey , Michael Balls BMC Medical Ethics. 2019;20(1):16. doi: 10.1186/s12910-019-0352-3 BACKGROUND: Even after several decades of human drug development, there remains an absence of published, substantial, comprehensive data to validate the use of …
Predicting human drug toxicity and safety via animal tests: can any one species predict drug toxicity in any other, and do monkeys help?
ReferenceJarrod Bailey , Michelle Thew , Michael Balls Alternatives to laboratory animals: ATLA. 2015;43(6):393-403. doi: 10.1177/026119291504300607 Animals are still widely used in drug development and safety tests, despite evidence for their lack of predictive …
Monkey-based research on human disease: the implications of genetic differences
ReferenceJarrod Bailey Alternatives to Laboratory Animals. 2014;42(5):287-317. doi: 10.1177/026119291404200504 Assertions that the use of monkeys to investigate human diseases is valid scientifically are frequently based on a reported 90-93% genetic similarity …
Advances in neuroscience imply that harmful experiments in dogs are unethical
ReferenceJarrod Bailey , Shiranee Pereira Journal of Medical Ethics. 2018;44(1):47-52. doi: 10.1136/medethics-2016-103630 Functional MRI (fMRI) of fully awake and unrestrained dog 'volunteers' has been proven an effective tool to understand the neural circuitry …
Modernizing Medical Research to Benefit People and Animals
ReferenceIsobel Hutchinson , Carla Owen , Jarrod Bailey Animals (Basel). 2022;12(9):1173. doi: 10.3390/ani12091173 In the context of widespread public and political concern around the use of animals in research, we sought to examine the scientific, ethical and …