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Cellular reprogramming as a tool to model human aging in a dish
ReferencePatricia R. Pitrez , Luis M. Monteiro , Oliver Borgogno , Xavier Nissan , Jerome Mertens , Lino Ferreira Nature Communications. 2024;15(1):1816. doi: 10.1038/s41467-024-46004-5 The design of human model systems is highly relevant to unveil the underlying …
Systematic estimation of biological age of in vitro cell culture systems by an age-associated marker panel
ReferenceChristiane Hartmann , Luise Herling , Alexander Hartmann , Verena Köckritz , Georg Fuellen , Michael Walter , Andreas Hermann Frontiers in Aging. 2023;4. doi: 10.3389/fragi.2023.1129107 Aging is a process that affects almost all multicellular organisms …
In vitro 3-D model based on extending time of culture for studying chronological epidermis aging
ReferenceMorgan Dos Santos , Elodie Metral , Aurélie Boher , Patricia Rousselle , Amélie Thepot , Odile Damour Matrix Biology. 2015;47:85-97. doi: 10.1016/j.matbio.2015.03.009 Skin aging is a complex phenomenon in which several mechanisms operate simultaneously. …
Opportunities for organoids as new models of aging
ReferenceJennifer L. Hu , Michael E. Todhunter , Mark A. LaBarge , Zev J. Gartner Journal of Cell Biology. 2017;217(1):39-50. doi: 10.1083/jcb.201709054 The biology of aging is challenging to study, particularly in humans. As a result, model organisms are used to …
Microphysiological Systems for Neurodegenerative Diseases in Central Nervous System
ReferenceMihyeon Bae , Hee-Gyeong Yi , Jinah Jang , Dong-Woo Cho Micromachines. 2020;11(9):855. doi: 10.3390/mi11090855 Neurodegenerative diseases are among the most severe problems in aging societies. Various conventional experimental models, including 2D and …
A functional aged human iPSC-cortical neuron model recapitulates Alzheimer's disease, senescence, and the response to therapeutics
ReferenceLeandro H. Gallo , Nesar Akanda , Kaveena Autar , Aakash Patel , Ian Cox , Haley A. Powell , Marcella Grillo , Natali Barakat , Dave Morgan , Xiufang Guo , James J. Hickman Alzheimer's & Dementia. 2024;20(9):5940-5960. doi: 10.1002/alz.14044 INTRODUCTION …
Recent advancements in microphysiological systems for neural development and disease
ReferenceKyla Nichols , Ryan Koppes , Abigail Koppes Current Opinion in Biomedical Engineering. 2020;14:42-51. doi: 10.1016/j.cobme.2020.05.003 Microphysiological systems (MPSs) of the nervous system provide physiologically relevant models for studying disease and …
Microfluidics-Based Systems in Diagnosis of Alzheimer’s Disease and Biomimetic Modeling
ReferenceYan Li , Danni Li , Pei Zhao , Krishnaswamy Nandakumar , Liqiu Wang , Youqiang Song Micromachines. 2020;11(9):787. doi: 10.3390/mi11090787 Early detection and accurate diagnosis of Alzheimer’s disease (AD) is essential for patient care and disease …
Accelerating the in vitro emulation of Alzheimer’s disease-associated phenotypes using a novel 3D blood-brain barrier neurosphere co-culture model
ReferenceEunkyung Clare Ko , Sarah Spitz , Francesca Michela Pramotton , Olivia M. Barr , Ciana Xu , Georgios Pavlou , Shun Zhang , Alice Tsai , Anna Maaser-Hecker , Mehdi Jorfi , Se Hoon Choi , Rudolph E. Tanzi , Roger D. Kamm Frontiers in Bioengineering and …
Modeling the neuroimmune system in Alzheimer’s and Parkinson’s diseases
ReferenceWendy Balestri , Ruchi Sharma , Victor A. da Silva , Bianca C. Bobotis , Annabel J. Curle , Vandana Kothakota , Farnoosh Kalantarnia , Maria V. Hangad , Mina Hoorfar , Joanne L. Jones , Marie-Ève Tremblay , Jehan J. El-Jawhari , Stephanie M. Willerth , …