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Vascularization of organoid microenvironments: Perfusable networks for organoid growth and maturation
ReferenceMarc Vila Cuenca , Merve Bulut , Christine L. Mummery , Valeria V. Orlova Current Opinion in Biomedical Engineering. 2025;34:100586. doi: 10.1016/j.cobme.2025.100586 Generation of functional vasculature within organoids is considered important for their …
Vascular network-inspired diffusible scaffolds for engineering functional midbrain organoids
ReferenceHongwei Cai , Chunhui Tian , Lei Chen , Yang Yang , Alfred Xuyang Sun , Kyle McCracken , Jason Tchieu , Mingxia Gu , Ken Mackie , Feng Guo Cell Stem Cell. 2025. doi: 10.1016/j.stem.2025.02.010 Organoids, 3D organ-like tissue cultures derived from stem …
Alzheimer’s Disease: Key Insights from Two Decades of Clinical Trial Failures
ReferenceC. Kwon Kim , Yin Rui Lee , Lynnett Ong , Michael Gold , Amir Kalali , Joydeep Sarkar Journal of Alzheimer’s Disease. 2022;87(1):83-100. doi: 10.3233/JAD-215699 Given the acknowledged lack of success in Alzheimer’s disease (AD) drug development over the …
Industry Adoption of Organoids and Organs-on-Chip Technology: Toward a Paradox of Choice
ReferenceKimberly A. Homan Advanced Biology. 2023;7(6):2200334. doi: 10.1002/adbi.202200334 During the last decade, organoid and organs-on-chip technologies have significantly enhanced the ability to model human biology in vitro. For the pharmaceutical industry, …
Advancing nonclinical innovation and safety in pharmaceutical testing
ReferenceElizabeth J. Baker , Nancy A. Beck , Ellen L. Berg , Helene D. Clayton-Jeter , P. Charukeshi Chandrasekera , J. Lowry Curley , Bruce A. Donzanti , Lorna C. Ewart , Jane M. Gunther , J. Gerry Kenna , Edward L. LeCluyse , Michael N. Liebman , Catherine L. …
Does the Stress of Laboratory Life and Experimentation on Animals Adversely Affect Research Data? A Critical Review
ReferenceJarrod Bailey Alternatives to Laboratory Animals. 11;46(5):291-305. doi: 10.1177/026119291804600501 Recurrent acute and/or chronic stress can affect all vertebrate species, and can have serious consequences. It is increasingly and widely appreciated that …
A cost-effective vessel-on-a-chip for high shear stress applications in vascular biology
ReferenceClarissa Becher , Martin Frauenlob , Florian Selinger , Peter Ertl , Marie-José Goumans , Gonzalo Sanchez-Duffhues Microvascular Research. 2025:104814. doi: 10.1016/j.mvr.2025.104814 The vascular endothelium is constantly subjected to hemodynamic forces, …
Differences in Frontal Network Anatomy Across Primate Species
ReferenceRachel L. C. Barrett , Matthew Dawson , Tim B. Dyrby , Kristine Krug , Maurice Ptito , Helen D'Arceuil , Paula L. Croxson , Philippa J. Johnson , Henrietta Howells , Stephanie J. Forkel , Flavio Dell'Acqua , Marco Catani Journal of Neuroscience. …
A molecular and cellular perspective on human brain evolution and tempo
ReferenceFeline W. Lindhout , Fenna M. Krienen , Katherine S. Pollard , Madeline A. Lancaster Nature. 2024;630(8017):596-608. doi: 10.1038/s41586-024-07521-x The evolution of the modern human brain was accompanied by distinct molecular and cellular …
Alopecia in three macaque species housed in a laboratory environment
ReferenceR. Kroeker , R. U. Bellanca , G. H. Lee , J. P. Thom , J. M. Worlein American journal of primatology. 2014;76(4):325-334. doi: 10.1002/ajp.22236 Alopecia is a persistent problem in captive macaque populations and despite recent interest, no factors have …