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Modeling heart rhythm using human engineered heart tissues
ReferenceChengyi Tu , Arianne Caudal , Yu Liu , Sanjiv M. Narayan , Joseph C. Wu Nature Protocols. 2025:1-24. doi: 10.1038/s41596-025-01217-w Heart rate is both an indicator and modulator of cardiovascular health. Prolonged elevation in heart rate or irregular …
Autologous Organoid-T Cell Co-Culture Platform for Modeling of Immune-Mediated Drug-Induced Liver Injury
ReferenceFadoua El Abdellaoui Soussi , Michael Brusilovsky , Emma Buck , W. Clark Bacon , Sina Dadgar , Aaron Fullerton , Victoria Marsh Durban , Riccardo Barrile , Michael A. Helmrath , Takanori Takebe , Adrian Roth , Magdalena Kasendra Advanced Science …
Translation of a Human-Based Malaria-on-a-Chip Phenotypic Disease Model for In Vivo Applications
ReferenceMichael J. Rupar , Hannah M. Hanson , Brianna L. Botlick , Narasimhan Sriram , Stephanie Rogers , Justin Zuniga , Zhanhe Liu , Steven J. Trimmer , Joseph M. Ciurca , Christopher J. Long , Christopher W. McAleer , Stephan Schmidt , Paola Favuzza , Philip …
Differential biomarker expression of blood and lymphatic vasculature in multi-organ-chips
ReferenceJonas Jäger , Maria Thon , Katharina Schimek , Uwe Marx , Susan Gibbs , Jasper J. Koning Scientific Reports. 2025;15(1):14492. doi: 10.1038/s41598-025-96367-y Since the blood and lymphatic endothelium regulates homeostasis and inflammation during health …
Stem cell research in space: Advancing regenerative medicine beyond Earth
ReferenceMaedeh Mozneb , Madelyn Arzt , Jemima Moses , Sean Escopete , Lauren Wiegand , Arun Sharma Cell Stem Cell. 2025;32(10):1491-1508. doi: 10.1016/j.stem.2025.09.001 https://www.cell.com/cell-stem-cell/abstract/S1934-5909(25)00332-7 Keywords disease modeling …
Mapping the ethical and sustainable transition in toxicology: a bibliometric analysis and a review of new approach methodologies
ReferenceRuxandra Malina Petrescu-Mag , Mathieu Vinken , Dacinia Crina Petrescu Archives of Toxicology. 2025. doi: 10.1007/s00204-025-04209-7 Toxicology is undergoing a paradigm shift, driven by the ethical imperative to reduce animal testing, the pursuit of …
Practical implementation and impact of the 4R principles in ethnopharmacology: Pursuing a more humane approach to research
ReferenceJimin Liu , Xiang Zai , Xiaqing Tian , Jiaxuan Li , Shipeng Yan , Taiyi Wang Frontiers in Pharmacology. 2025;16. doi: 10.3389/fphar.2025.1543316 Ethnopharmacology, a discipline focused on studying the medicinal use of natural materials by humans, plays a …
New approach methodologies in human health risk assessment across European regulatory frameworks: Status quo, barriers and drivers for regulatory acceptance and use
ReferenceAngela Bearth , Nicolas Roth , Tom Jansen , Laura Holden , Aleksandra Čavoški , Emma Di Consiglio , Ingrid Hauzenberger , Robert Lee , Enrico Mombelli , Olga Tcheremenskaia , Lina Wendt-Rasch , Martin F. Wilks Environment International. 2025;196:109279. …
ReBiA—Robotic Enabled Biological Automation: 3D Epithelial Tissue Production
ReferenceLukas Königer , Christoph Malkmus , Dalia Mahdy , Thomas Däullary , Susanna Götz , Thomas Schwarz , Marius Gensler , Niklas Pallmann , Danjouma Cheufou , Andreas Rosenwald , Marc Möllmann , Dieter Groneberg , Christina Popp , Florian Groeber-Becker , …
Animal models in neuroscience with alternative approaches: Evolutionary, biomedical, and ethical perspectives
ReferenceSabina Neziri , Ahmet Efe Köseoğlu , Gülsüm Deniz Köseoğlu , Buminhan Özgültekin , Nehir Özdemir Özgentürk Animal Models and Experimental Medicine. 2024;7(6):868-880. doi: 10.1002/ame2.12487 Animal models have been a crucial tool in neuroscience research …