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Addressing animal methods bias through government-led initiatives
ReferenceJessica S. Kopew , Merel Ritskes-Hoitinga , Mikalah Singer , Emily R. Trunnell , Gabby Vidaurre , Catharine E. Krebs Frontiers in Toxicology. 2026;8. doi: 10.3389/ftox.2026.1761759 Peer review aims to ensure that high-quality research is funded, …
A Patient-Derived Organ-on-Chip Platform for Modeling the Tumor Microenvironment and Drug Responses in Pancreatic Cancer
ReferenceDarbaz Adnan , Natan Roberto de Barros , Luca S. Santovito , Xuhong Cheng , Kristi M. Lawrence , Mariah K. Barnett , Martine D. Boetto , Neal Mehta , Ajaypal Singh , Lin Cheng , Xiangsheng Huang , Faraz Bishehsari Advanced Science. ;n/a(n/a):e08934. doi: …
From organoid culture to manufacturing: technologies for reproducible and scalable organoid production
ReferenceDohui Kim , Jaeseung Youn , Juhyeok Kim , Jeongmin Lee , Jangwon Yoon , Dong Sung Kim npj Biomedical Innovations. 2026;3(1):12. doi: 10.1038/s44385-025-00054-6 In this review, we systematically categorize diverse organoid engineering strategies—including …
Derivation of a Point of Departure using NAMs for application in Quantitative Risk Assessment of fragrance materials
ReferenceAndreas Natsch , Peter Griem , Amaia Irizar , James Bridges , Matthias Vey , Isabelle Lee , Anne Marie Api , Petra Kern , Ian Kimber Regulatory Toxicology and Pharmacology. 2026:106052. doi: 10.1016/j.yrtph.2026.106052 Skin sensitization is a key endpoint …
Status of animal experimentation in nutrition and dietetic research: Policies of 100 leading journals and new approach methodologies
ReferenceMaximilian Andreas Storz , Elizabeth Dean Accountability in Research. 2025;32(8):1545-1563. doi: 10.1080/08989621.2024.2398104 Given animal research is challenged with inadequacies, e.g., animal-to-human knowledge translation, ethical considerations, and …
Modeling immune lineage co-development in human pluripotent stem cell-derived liver organoids
ReferenceMilad Rezvani , Susanna Quach , Kyle Lewis , Norikazu Saiki , Chuqing Xue , Masaki Kimura , Kentaro Iwasawa , Julian Weihs , Tahlil Elzobair , Hasan Al Reza , Yuqi Cai , RanRan Zhang , Yuka Milton , Praneet Chaturvedi , Konrad Thorner , Ramesh C. Nayak , …
Managing change while phasing out animal testing in chemical safety assessments – a collection of stakeholder experiences and expectations
ReferenceElisabet Berggren , Andrew P. Worth NAM Journal. 2026;2:100079. doi: 10.1016/j.namjnl.2026.100079 This is a summary of a series of bilateral discussions between the European Commission and different stakeholders in the context of developing the EU roadmap …
Lost in NAMs-lation: A review of animal-free science definitions
ReferenceDonna S. Macmillan , Phi Holcomb , Kristie M. Sullivan ALTEX - Alternatives to Animal Experimentation. 2026. doi: 10.14573/altex.2512221 The use of terminology related to animal-free science has grown rapidly over the past two decades; however, …
Emerging therapies for lung adenocarcinoma: Mechanistic and efficacy insights from spheroid-based <i>in vitro</i> models
ReferencePooja Sawant , Ratnesh Jain , Prajakta Dandekar Journal of Drug Delivery Science and Technology. 2026;117:108030. doi: 10.1016/j.jddst.2026.108030 The persistent challenges of drug resistance, tumor heterogeneity, and poor predictability of traditional 2D …
Lineage-resolved atlas of the developing human cortex
ReferenceMatthew G. Keefe , Marilyn R. Steyert , Tomasz J. Nowakowski Nature. 2025;647(8088):194-202. doi: 10.1038/s41586-025-09033-8 The human neocortex is composed of diverse cell types1 that are generated during development according to spatially and temporally …