Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten-van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren-Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis-Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries

doi: 10.1002/smtd.202502114

This study shows that human iPSC-derived endothelial cells acquire a functional blood–brain barrier phenotype when co-cultured with brain pericytes and stimulated with CHIR-99021, a Wnt/β-catenin act...

https://onlinelibrary.wiley.com/doi/10.1002/smtd.202502114

Library Collection(s)

Nervous system