Humans

Lorna Ewart, Adrian Roth. Opportunities and challenges with microphysiological systems: a pharma end-user perspective. Nature Reviews. Drug Discovery. 2021;20(5):327-328. doi:10.1038/d41573-020-00030-2

Hongbing Wang, Paul C. Brown, Edwin C. Y. Chow, et al. 3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration. Clinical and Translational Science. 2021;14(5):1659-1680. doi:10.1111/cts.13066

Tomasz Kostrzewski, Sophie Snow, Anya Lindström Battle, et al. Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system. Communications Biology. 2021;4(1):1080. doi:10.1038/s42003-021-02616-x

Foluwasomi A. Oyefeso, Alysson R. Muotri, Christopher G. Wilson, Michael J. Pecaut. Brain organoids: A promising model to assess oxidative stress-induced central nervous system damage. Developmental Neurobiology. 2021;81(5):653-670. doi:10.1002/dneu.22828

Jonas C. Schupp, Taylor S. Adams, Carlos Cosme, et al. Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung. Circulation. 2021;144(4):286-302. doi:10.1161/CIRCULATIONAHA.120.052318

Louisa Helms, Silvia Marchiano, Ian B. Stanaway, et al. Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations. JCI insight. 2021;6(24):e154882. doi:10.1172/jci.insight.154882

Jarrod Bailey. Biomedical Research Must Change - But a Shift Toward Human-specific Research Methods Is Only Part of What Is Needed. Alternatives to Laboratory Animals. 2021;49(3):69-72. doi:10.1177/02611929211030417

Abbas Shafiee, Lida Moradi, Mayasari Lim, Jason Brown. Coronavirus disease 2019: A tissue engineering and regenerative medicine perspective. Stem Cells Translational Medicine. 2021;10(1):27-38. doi:10.1002/sctm.20-0197

Yuling Han, Xiaohua Duan, Liuliu Yang, et al. Identification of SARS-CoV-2 inhibitors using lung and colonic organoids. Nature. 2021;589(7841):270-275. doi:10.1038/s41586-020-2901-9

Benoit Souquet, Matthieu Opitz, Benoit Vianay, Stéphane Brunet, Manuel Théry. Manufacturing a Bone Marrow-On-A-Chip Using Maskless Photolithography. Methods in Molecular Biology (Clifton, N.J.). 2021;2308:263-278. doi:10.1007/978-1-0716-1425-9_20