Drug development

Julia Y. Co, Jessica A. Klein, Serah Kang, Kimberly A. Homan. Toward Inclusivity in Preclinical Drug Development: A Proposition to Start with Intestinal Organoids. Advanced Biology. 2023;7(12):2200333. doi:10.1002/adbi.202200333

Peter S. R. Wright, Katharine A. Briggs, Robert Thomas, et al. Statistical analysis of preclinical inter-species concordance of histopathological findings in the eTOX database. Regulatory Toxicology and Pharmacology. 2023;138:105308. doi:10.1016/j.yrtph.2022.105308

Carla Cuní-López, Romal Stewart, Anthony R. White, Hazel Quek. 3D in vitro modelling of human patient microglia: A focus on clinical translation and drug development in neurodegenerative diseases. Journal of Neuroimmunology. 2023;375:578017. doi:10.1016/j.jneuroim.2023.578017

Marit Keuper-Navis, Markus Walles, Birk Poller, et al. The application of organ-on-chip models for the prediction of human pharmacokinetic profiles during drug development. Pharmacological Research. 2023;195:106853. doi:10.1016/j.phrs.2023.106853

Jack W. Scannell, James Bosley, John A. Hickman, et al. Predictive validity in drug discovery: what it is, why it matters and how to improve it. Nature Reviews Drug Discovery. 2022;21(12):915-931. doi:10.1038/s41573-022-00552-x

Emily Sutterby, Peter Thurgood, Sara Baratchi, Khashayar Khoshmanesh, Elena Pirogova. Evaluation of in vitro human skin models for studying effects of external stressors and stimuli and developing treatment modalities. VIEW. 2022;3(2):20210012. doi:10.1002/VIW.20210012

Lorna Ewart, Adrian Roth. Opportunities and challenges with microphysiological systems: a pharma end-user perspective. Nature Reviews. Drug Discovery. 2021;20(5):327-328. doi:10.1038/d41573-020-00030-2

Désirée H. Veening-Griffioen, Guilherme S. Ferreira, Wouter P. C. Boon, et al. Tradition, not science, is the basis of animal model selection in translational and applied research. ALTEX. 2021;38(1):49-62. doi:10.14573/altex.2003301

Valentina Paloschi, Maria Sabater-Lleal, Heleen Middelkamp, et al. Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases. Cardiovascular Research. 2021;117(14):2742-2754. doi:10.1093/cvr/cvab088

Argus M. Sun, Tyler Hoffman, Bao Q. Luu, Nureddin Ashammakhi, Song Li. Application of lung microphysiological systems to COVID-19 modeling and drug discovery: a review. Bio-Design and Manufacturing. 2021;4(4):757-775. doi:10.1007/s42242-021-00136-5