Drug development

Catharine E. Krebs, Kathrin Herrmann. Confronting the bias towards animal experimentation (animal methods bias). Frontiers in Drug Discovery. 2024;4. doi:10.3389/fddsv.2024.1347798

Eric Vallabh Minikel, Jeffery L. Painter, Coco Chengliang Dong, Matthew R. Nelson. Refining the impact of genetic evidence on clinical success. Nature. 2024:1-6. doi:10.1038/s41586-024-07316-0

Thomas Hartung. The (misleading) role of animal models in drug development. Frontiers in Drug Discovery. 2024;4. doi:10.3389/fddsv.2024.1355044

Pelin L. Candarlioglu, Louise Delsing, Lauren Gauthier, et al. Application of microphysiological systems for nonclinical evaluation of cell therapies. Alternatives to Animal Experimentation. 2024;41(3):469-484. doi:10.14573/altex.2402201

Katerina Trajanoska, Claude Bhérer, Daniel Taliun, Sirui Zhou, J. Brent Richards, Vincent Mooser. From target discovery to clinical drug development with human genetics. Nature. 2023;620(7975):737-745. doi:10.1038/s41586-023-06388-8

Peter S. R. Wright, Katharine A. Briggs, Robert Thomas, et al. Statistical analysis of preclinical inter-species concordance of histopathological findings in the eTOX database. Regulatory Toxicology and Pharmacology. 2023;138:105308. doi:10.1016/j.yrtph.2022.105308

Carla Cuní-López, Romal Stewart, Anthony R. White, Hazel Quek. 3D in vitro modelling of human patient microglia: A focus on clinical translation and drug development in neurodegenerative diseases. Journal of Neuroimmunology. 2023;375:578017. doi:10.1016/j.jneuroim.2023.578017

Marit Keuper-Navis, Markus Walles, Birk Poller, et al. The application of organ-on-chip models for the prediction of human pharmacokinetic profiles during drug development. Pharmacological Research. 2023;195:106853. doi:10.1016/j.phrs.2023.106853

Jack W. Scannell, James Bosley, John A. Hickman, et al. Predictive validity in drug discovery: what it is, why it matters and how to improve it. Nature Reviews Drug Discovery. 2022;21(12):915-931. doi:10.1038/s41573-022-00552-x

Emily Sutterby, Peter Thurgood, Sara Baratchi, Khashayar Khoshmanesh, Elena Pirogova. Evaluation of in vitro human skin models for studying effects of external stressors and stimuli and developing treatment modalities. VIEW. 2022;3(2):20210012. doi:10.1002/VIW.20210012