Drug development

Ryan Posey, Alican Özkan, Donald E. Ingber. Human organ-on-a-chip technology as a catalyst for drug discovery. Advanced Drug Delivery Reviews. 2026;236:115920. doi:10.1016/j.addr.2026.115920

Laura Lotfi, T. William O’Neill, Angela Wilcox, Steven Bulera. Virtual control groups in nonclinical research: A Re-analysis of 20 studies using virtual control group data. Regulatory Toxicology and Pharmacology. 2026;168:106077. doi:10.1016/j.yrtph.2026.106077

Alastair G. Stewart, Avanka Gunatilaka, Bryan Gao. Should culture media for microphysiological systems be nutritionally physiological? Nature Reviews Bioengineering. 2025;3(5):357-358. doi:10.1038/s44222-025-00290-w

Thomas Hartung, Lena Smirnova. A path forward advancing microphysiological systems. ALTEX - Alternatives to animal experimentation. 2025;42(2):183-203. doi:10.14573/altex.2504091

Surat Parvatam, Francesca Pistollato, Lindsay J. Marshall, et al. Human-based complex in vitro models: their promise and potential for rare disease therapeutics. Frontiers in Cell and Developmental Biology. 2025;13. doi:10.3389/fcell.2025.1526306

Hiroshi Kimura, Masaki Nishikawa, Naokata Kutsuzawa, et al. Advancements in Microphysiological systems: Exploring organoids and organ-on-a-chip technologies in drug development -focus on pharmacokinetics related organs-. Drug Metabolism and Pharmacokinetics. 2025;60:101046. doi:10.1016/j.dmpk.2024.101046

Aakash Patel, Suruchi Poddar, Daniel Nierenberg, et al. Microphysiological system to address the opioid crisis: A novel multi-organ model of acute opioid overdose and recovery. Current Research in Toxicology. 2025;8:100209. doi:10.1016/j.crtox.2024.100209

Jacintha Shenton, Imein Bousnina, Michael Oropallo, et al. Opportunities and insights from pharmaceutical companies on the current use of new approach methodologies in nonclinical safety assessment. Drug Discovery Today. 2025;30(4):104328. doi:10.1016/j.drudis.2025.104328

William C. Wright, Min Pan, Gregory A. Phelps, et al. An open-source screening platform accelerates discovery of drug combinations. Nature Communications. 2025;16(1):11005. doi:10.1038/s41467-025-66223-8

Kang Zhang, Xin Yang, Yifei Wang, et al. Artificial intelligence in drug development. Nature Medicine. 2025;31(1):45-59. doi:10.1038/s41591-024-03434-4