Drug Evaluation, Preclinical

Elizabeth J. Baker, Nancy A. Beck, Ellen L. Berg, et al. Advancing nonclinical innovation and safety in pharmaceutical testing. Drug Discovery Today. 2019;24(2):624-628. doi:10.1016/j.drudis.2018.11.011

Michael Balls, Jarrod Bailey, Robert D. Combes. How viable are alternatives to animal testing in determining the toxicities of therapeutic drugs? Expert Opinion on Drug Metabolism & Toxicology. 2019;15(12):985-987. doi:10.1080/17425255.2019.1694662

Jun-Hwan Yoo, Mark Donowitz. Intestinal enteroids/organoids: A novel platform for drug discovery in inflammatory bowel diseases. World Journal of Gastroenterology. 2019;25(30):4125-4147. doi:10.3748/wjg.v25.i30.4125

Shurong Hou, Hervé Tiriac, Banu Priya Sridharan, et al. Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening. SLAS discovery: advancing life sciences R & D. 2018;23(6):574-584. doi:10.1177/2472555218766842

Pandora Pound, Merel Ritskes-Hoitinga. Is it possible to overcome issues of external validity in preclinical animal research? Why most animal models are bound to fail. Journal of Translational Medicine. 2018;16(1):304. doi:10.1186/s12967-018-1678-1

William G. Kaelin. Common pitfalls in preclinical cancer target validation. Nature Reviews. Cancer. 2017;17(7):425-440. doi:10.1038/nrc.2017.32

Jarrod Bailey, Michelle Thew, Michael Balls. Predicting human drug toxicity and safety via animal tests: can any one species predict drug toxicity in any other, and do monkeys help? Alternatives to laboratory animals: ATLA. 2015;43(6):393-403. doi:10.1177/026119291504300607

Jarrod Bailey, Michelle Thew, Michael Balls. An analysis of the use of animal models in predicting human toxicology and drug safety. Alternatives to Laboratory Animals. 2014;42(3):181-199. doi:10.1177/026119291404200306

Valerie C. Henderson, Jonathan Kimmelman, Dean Fergusson, Jeremy M. Grimshaw, Dan G. Hackam. Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments. PLoS Medicine. 2013;10(7):e1001489. doi:10.1371/journal.pmed.1001489

Victoria E. O’Collins, Malcolm R. Macleod, Geoffrey A. Donnan, Laura L. Horky, Bart H. van der Worp, David W. Howells. 1,026 experimental treatments in acute stroke. Annals of Neurology. 2006;59(3):467-477. doi:10.1002/ana.20741